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Porous rods (6mm in length and 4mm in diameter) of calcium polyphosphate (CPP) made by gravity sintering of particles in the size ranges of 45-105, 105-150, and 150-250μm and with initial volume percent porosity in the range of 35-45% were implanted in the distal femur of New Zealand white rabbits. In an initial experiment, four rabbits implanted with rods made from coarse particles (150-250μm) were...
The aim of this study was to investigate the effect of a third generation bisphosphonate (CGP 42'446) on the bone and cartilage of the knee in a rabbit model of inflammatory arthritis (carrageenin arthritis model). Mature female New Zealand white rabbits were divided into two groups, control (n=7) or experimental (n=8). Both groups received 7 intra-articular injections of 0.3 ml of 1% carrageenin...
Bone loss resulting from immobilization or disuse has been shown in humans following paralysis or bedrest. We have developed a new model of immobilization in the dog which is reversible and we have studied the effect of pamidronate (APD) in this model. Twelve mature beagle dogs were fitted with specially designed mesh jackets. These jackets were used to bind the left forelimb against the body of...
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