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Laser Doppler flowmetry (LDF) has been used to assess cortical bone blood flow in various clinical situations, such as osteomyelitis and osteonecrosis. Standard metal-sheathed probes containing optical fibers, applied to cortical bone for perfusion measurements, require direct exposure of the bone surface for each measurement, making nonanesthetized assessments over time impractical. Implantable optical...
The aim of this study was to investigate the effect of a third generation bisphosphonate (CGP 42'446) on the bone and cartilage of the knee in a rabbit model of inflammatory arthritis (carrageenin arthritis model). Mature female New Zealand white rabbits were divided into two groups, control (n=7) or experimental (n=8). Both groups received 7 intra-articular injections of 0.3 ml of 1% carrageenin...
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