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Fracture risk is associated with bone mineral density (BMD) and with other indices of bone strength, including hip geometry. While the heritability and associated fracture risk of BMD are well described, less is known about genetic influences of bone geometry. We derived hip structural phenotypes using the Hip Structural Analysis program (HSA) and performed autosome-wide linkage analysis of hip geometric...
This paper introduces a new method for computing large numbers of LOD scores in linkage analysis. The LOD score method is commonly used in genetic linkage analysis to associate functionality of genes to their locations on chromosomes. A LOD score is a log 10 likelihood ratio of linkage to no linkage. Instead of calculating values of likelihoods of linkage and no linkage under given values of genetic...
Genetic linkage analysis is a recombinant technology used for mapping disease genes on the genome, based on genotypic and phenotypic data collected from families that have affected members. The LOD score is a commonly used statistic in genetic linkage analysis. LOD scores are computed assuming specific values for genetic parameters. However, for complex disorders the specified parameter values are...
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