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One issue of synthetic biology concerns the ability to predict the functioning of a new biosystem, right from the design stage. To do so, many models are developed. This paper focuses on the phenomenon of biological noise, which is actually not integrated in the standard models. This paper describes the different biological noises and draws a comparison between them and microelectronic noises. The...
We recently demonstrated that it is possible to model and to simulate biological functions using hardware description languages (and associated simulators) traditionally used for micro-electronics. The main drawback of these languages is that they do not support partial differential equations. However, for several applications in biology, space-dependent quantities are unavoidable. This paper deals...
Lab-on-chips (LOCs) are small systems, which integrate, in the same device, several functions involving chemical analysis with bio-processing functionalities typically performed in a laboratory. As a consequence, it is a multi-domain system that can be described and designed with VHDL-AMS, a hardware description language that natively supports electronics, thermics and fluidics. On the other hand,...
Research and development in life sciences domain brings every day many innovations. Some of them have been enabled (or improved) by the micro-electronics. Several examples are described in this paper. A big challenge in the design of such systems is that the biological part cannot be uncoupled from the rest of the system during the design process. The integration of biological parts in system's design...
Synthetic biology is a new field of biotechnology which aims to apply engineering design processes for the development of new artificial biological functions. In this domain, the development of automated design tools is a big challenge. This paper deals with a new approach based on the description of elementary biological mechanisms through fuzzy logic, which is an intermediate description level between...
Currently, several levels of abstraction can be used to model targeted biological application and their associated assembly of elementary biological components (i.e.: BioBricks). The highest one uses the analogy between the behavior of biological mechanism and digital gates. The lowest one uses ordinary differential equations to get accurate and quantitative results. To bridge the gap between these...
Synthetic biology is an emerging field at the interface between biotechnology and engineering sciences. It aims at designing new biological functions by assembling elementary parts (DNA sequences) based on design approaches inspired from those used for the design of complex microsystems. The development of efficient tools to support the design is therefore a technological bottleneck that could prevent...
Nowadays, synthetic biology is a hot research topic. Each day, progresses are made to improve the complexity of artificial biological functions in order to tend to complex biodevices and biosystems. Up to now, these systems are handmade by bioengineers, which require strong technical skills and leads to nonreusable development. Besides, scientific fields that share the same design approach, such as...
A fully explicit and physics-based model has been developed for arbitrary shapes of lightly doped long-channel nonplanar multigate MOSFETs (MuGFETs). Through the definition of equivalent geometrical parameters, MuGFETs as quadruple-gate (QG), triple-gate (TG), triangular gate, cylindrical gate-all-around (GAA), and FinFETs, are mapped into the symmetric double-gate (DG) MOSFET topology without the...
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