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Background
The development of benign prostatic hyperplasia (BPH) and medication‐refractory lower urinary tract symptoms (LUTS) remain poorly understood. This study attempted to characterize the pathways associated with failure of medical therapy for BPH/LUTS.
Methods
Transitional zone tissue levels of cholesterol and steroids were measured in patients who failed medical therapy for BPH/LUTS and...
Cholesterol is synthesized endogenously in the brain in a complex pathway that starts with the condensation of acetate and acetoacetate. The last step in this pathway is the conversion of 7-dehydrocholesterol (7-DHC) into cholesterol, a step catalyzed by the enzyme dehydrocholesterol reductase 7 (DHCR7). Mutations in this enzyme lead to the accumulation of 7-DHC, a hallmark of the disorder known as...
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