Cholesterol is synthesized endogenously in the brain in a complex pathway that starts with the condensation of acetate and acetoacetate. The last step in this pathway is the conversion of 7-dehydrocholesterol (7-DHC) into cholesterol, a step catalyzed by the enzyme dehydrocholesterol reductase 7 (DHCR7). Mutations in this enzyme lead to the accumulation of 7-DHC, a hallmark of the disorder known as...
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