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Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4 + T-cell clones revealed marked differences in susceptibility to SIV mac 239 infection. We investigated whether different levels of CCR5 expression account for clonal differences in SIV mac 239 susceptibility. Macaque CD4 + T-cells...
CD8 + T lymphocytes (CTL) play a role in controlling HIV/SIV infection. CTL antiviral activity is dependent on recognition of antigenic peptides associated with MHC class I molecules on infected target cells, and CTL activation can be impaired by Nef-mediated down-regulation of MHC class I molecules. We tested the ability of a series of rhesus macaque CD8 + T-cell clones specific for...
CD8 + cytotoxic T lymphocytes (CTL) play an important role in controlling virus replication in HIV- and SIV-infected humans and monkeys, respectively. Three well-studied SIV CTL determinants are the two Mamu A ⁎ 01-restricted epitopes Gag CM9 and Tat SL8, and the Mamu B ⁎ 17-restricted epitope Nef IW9. Point mutations leading to amino acid replacements in these epitopes have...
CD8 + cytotoxic T lymphocyte (CTL) responses play an important role in controlling the replication of primate lentiviruses. Induction of these responses is a key objective for most current AIDS vaccine approaches. Despite a variety of approaches for measuring properties and activities of CTL, the functions responsible for controlling viral replication in vivo have not been clearly identified...
To establish long-term, antigen-specific T-cell lines and clones, we selectively immortalized antigen-responsive T cells from human peripheral blood mononuclear cells (PBMCs). PBMCs were stimulated with either alloantigen or soluble antigen, then infected with a murine leukemia virus-based retroviral vector carrying an immortalizing gene, either the Tax gene from human T-cell leukemia virus type 1,...
The lack of a well-behaved permanent, adherent, nontransformed chicken cell line has made some experiments with avian leukosis–sarcoma viruses (ASLV) and vectors considerably more difficult. The EV-O-derived line, DF-1, supports the efficient replication of subgroups (A), (B), and (C) ASLV, as well as amphotrophic murine leukemia virus and an ASLV-derived vector that has itsenvgene derived from theenvgene...
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