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Voltage-gated Na + channels are major targets of G protein-coupled receptor (GPCR)-initiated signaling cascades. These cascades act principally through protein kinase-mediated phosphorylation of the channel α subunit. Phosphorylation reduces Na + channel availability in most instances without producing major alterations of fast channel gating. The nature of this change in availability...
Activation of D1-like dopamine (DA) receptors reduces peak Na + current in hippocampal neurons voltage-dependent in a manner via phosphorylation of the α subunit. This modulation is dependent upon activation of cAMP-dependent protein kinase (PKA) and requires phosphorylation of serine 573 (S573) in the intracellular loop connecting homologous domains I and II (L I-II ...
Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-isolated hippocampal neurons using whole-cell voltage-clamp recording. Application...
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