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Persistent Na + currents are thought to be important for integration of neuronal responses. Here, we show that βγ subunits of G proteins can induce persistent Na + currents. Coexpression of Gβ 2 γ 3 , Gβ 1 γ3, or Gβ 5 γ 3 , but not Gβ 1 γ 1 subunits with rat brain type IIA Na + channel α subunits in tsA-201 cells greatly...
Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-isolated hippocampal neurons using whole-cell voltage-clamp recording. Application...