Search results for: Paul D. Soloway

Items from 1 to 12 out of 12 results

article

Dynamic regulation of chromatin accessibility during melanocyte stem cell activation

Seoyeon Lee, Luye An, Paul D. Soloway, Andrew C. White

Pigment Cell & Melanoma Research > 36 > 6 > 531 - 541

Melanocyte stem cells (McSCs) of the hair follicle are necessary for hair pigmentation and can serve as melanoma cells of origin when harboring cancer‐driving mutations. McSCs can be released from quiescence, activated, and undergo differentiation into pigment‐producing melanocytes during the hair cycle or due to environmental stimuli, such as ultraviolet‐B (UVB) exposure. However, our current understanding...

article

Imprinted DNA methylation reconstituted at a non-imprinted locus

David H. Taylor, Chelsea M. McLean, Warren L. Wu, Alex B. Wang, more

Epigenetics & Chromatin > 2016 > 9 > 1 > 1-9

Background In mammals, tight regulation of cytosine methylation is required for embryonic development and cellular differentiation. The trans-acting DNA methyltransferases that catalyze this modification have been identified and characterized; however, these proteins lack sequence specificity, leaving the mechanism of targeting unknown. A cis-acting regulator within the Rasgrf1 imprinting control...

article

Long non‐coding RNA regulation of reproduction and development

David H. Taylor, Erin Tsi‐Jia Chu, Roman Spektor, Paul D. Soloway

Molecular Reproduction and Development > 82 > 12 > 932 - 956

Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene regulation. Studies conducted over a decade ago revealed that maturation of spliced, polyadenylated coding mRNA occurs by reactions involving small nuclear RNAs and small nucleolar RNAs; mRNA translation depends on activities mediated by transfer RNAs and ribosomal RNAs, subject to negative regulation by micro RNAs;...

article

Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells

Xiao Li, Jinquan Wang, Zheng Jiang, Feng Guo, more

Gene > 2015 > 570 > 2 > 191-198

The positive regulatory domain containing 16 (PRDM16) is commonly regarded as a “switch” controlling the transdifferentiation of myoblasts to brown adipocytes. The N-positive regulatory (PR) domain, which is highly homologous to SET domain, is a characteristic structure for the PRDM family.Many SET domain containing proteins and several PRDM members have been found to possess histone methyltransferase...

article

Single molecule and single cell epigenomics

Byung-Ryool Hyun, John L. McElwee, Paul D. Soloway

Methods > 2015 > 72 > Complete > 41-50

Dynamically regulated changes in chromatin states are vital for normal development and can produce disease when they go awry. Accordingly, much effort has been devoted to characterizing these states under normal and pathological conditions. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most widely used method to characterize where in the genome transcription factors, modified...

article

Possible chemical initiators of cognitive dysfunction in phenylketonuria, Parkinson’s disease and Alzheimer’s disease

Albert H. Soloway, Paul D. Soloway, Victor D. Warner

Medical Hypotheses > 2013 > 81 > 4 > 690-694

Though a great deal is known of the pathophysiology of phenylketonuria (PKU), Parkinson’s disease (PD) and Alzheimer’s disease (AD) very little is known regarding possible chemical species responsible for initiating the cascade of events that ultimately cause cognitive dysfunction. Can these be viewed as inborn errors in metabolism, occurring at various stages in the life cycle, analogous to adult...

article

Single Molecule Epigenetic Analysis in a Nanofluidic Channel

Benjamin R. Cipriany, Ruqian Zhao, Patrick J. Murphy, Stephen L. Levy, more

Analytical Chemistry > 2010 > 82 > 6 > 2480 - 2487

article

Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1

Nadia M. Drake, Yoon Jung Park, Aditya S. Shirali, Thomas A. Cleland, more

Mammalian Genome > 2009 > 20 > 9-10 > 654-663

Rasgrf1 is imprinted and expressed preferentially from the paternal allele in neonatal mouse brain. At weaning, expression becomes biallelic. Using a mouse model, we assayed the effects of perturbing imprinted Rasgrf1 expression in mice with the following imprinted expression patterns: monoallelic paternal (wild type), monoallelic maternal (maternal only), biallelic (both alleles transcribed), and...

article

Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates myogenesis and β1 integrin expression in vitro

Gentian Lluri, Garret D. Langlois, Paul D. Soloway, Diane M. Jaworski

Experimental Cell Research > 2008 > 314 > 1 > 11-24

Myogenesis in vitro involves myoblast cell cycle arrest, migration, and fusion to form multinucleated myotubes. Extracellular matrix (ECM) integrity during these processes is maintained by the opposing actions of matrix metalloproteinase (MMP) proteases and their inhibitors, the tissue inhibitor of metalloproteinases (TIMPs). Here, we report that TIMP-2, MMP-2, and MT1-MMP are differentially expressed...

article

Persistent Macrophage/Microglial Activation and Myelin Disruption after Experimental Autoimmune Encephalomyelitis in Tissue Inhibitor of Metalloproteinase-1-Deficient Mice

Stephen J. Crocker, Jason K. Whitmire, Ricardo F. Frausto, Parntip Chertboonmuang, more

The American Journal of Pathology > 2006 > 169 > 6 > 2104-2116

Increased leukocyte trafficking into the parenchyma during inflammatory responses in the central nervous system (CNS) is facilitated by the extracellular proteolytic activities of matrix metalloproteinases that are regulated, in part, by the endogenous tissue inhibitors of metalloproteinases (TIMPs). In experimental autoimmune encephalomyelitis (EAE), TIMP-1 gene expression is induced in astrocytes...

article

Inactivation of the Murine Pyruvate Dehydrogenase (Pdha1) Gene and Its Effect on Early Embryonic Development

Mark T. Johnson, Saleh Mahmood, Susannah L. Hyatt, Hsin-Sheng Yang, more

Molecular Genetics and Metabolism > 2001 > 74 > 3 > 293-302

A deficiency of pyruvate dehydrogenase complex (PDC) in humans results in lactic acidosis and neurological dysfunction that frequently results in death during infancy. Using gene targeting technology, a silent mutation was introduced into the murine X-linked Pdha1 gene that encodes the α subunit of the pyruvate dehydrogenase or E1 component of the complex. Two loxP sequences were introduced into intronic...

article

Differential Roles of TIMP-4 and TIMP-2 in Pro-MMP-2 Activation by MT1-MMP

Sonia Hernandez-Barrantes, Yoichiro Shimura, Paul D. Soloway, QingXiang Amy Sang, more

Biochemical and Biophysical Research Communications > 2001 > 281 > 1 > 126-130

The tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of MMP enzymatic activity. However, TIMP-2 can promote the activation of pro-MMP-2 by MT1-MMP. This process is mediated by the formation of a complex between MT1-MMP, TIMP-2, and pro-MMP-2. Binding of TIMP-2 to active MT1-MMP also inhibits the autocatalytic turnover of MT1-MMP on the cell surface. Thus, under certain conditions,...

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