Pigment Cell & Melanoma Research

Items from 1 to 20 out of 1,491 results

article

The pigmented road ahead – success through collaboration

Ze’ev Ronai

Pigment Cell & Melanoma Research > 23 > 1 > 1 - 2

article

Inducible expression of ^V600EBraf using tyrosinase‐driven Cre recombinase results in embryonic lethality

Nathalie Dhomen, Silvy Da Rocha Dias, Robert Hayward, Lesley Ogilvie, more

Pigment Cell & Melanoma Research > 23 > 1 > 112 - 120

We recently demonstrated that expression of ^V600EBraf in mature mouse melanocytes induces melanoma. Here, we show that expression of ^V600EBraf using the tyrosinase promoter leads to an unexpected embryonic lethality, with the animals dying before, at, or shortly after birth. The mice suffer from a range of developmental defects in the skin, the brain, the eyes and the heart, tissues that are normally...

article

Androgen, estrogen and progesterone receptors in acquired bilateral nevus of Ota‐like macules

Ting‐feng Long, Liu Liu, Li He, Li‐da Shen, more

Pigment Cell & Melanoma Research > 23 > 1 > 144 - 146

article

Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma

Minoru Takata, Hiroshi Murata, Toshiaki Saida

Pigment Cell & Melanoma Research > 23 > 1 > 64 - 71

The Clark model for melanoma progression emphasizes a series of histopathological changes beginning from benign melanocytic nevus to melanoma via dysplastic nevus. Several models of the genetic basis of melanoma development and progression are based on this Clark’s multi‐step model, and predict that the acquisition of a BRAF mutation can be a founder event in melanocytic neoplasia. However, our recent...

article

A colorful explanation for atrial arrhythmias

Benjamin F. Remo, Glenn I. Fishman

Pigment Cell & Melanoma Research > 23 > 1 > 3 - 4

article

Melanoma from bench to bedside: meeting report from the 6th international melanoma congress

D. E. Fisher, R. Barnhill, F. S. Hodi, M. Herlyn, more

Pigment Cell & Melanoma Research > 23 > 1 > 14 - 26

article

High molecular weight–melanoma‐associated antigen as a biomarker of desmoplastic melanoma

Yasufumi Goto, Takaaki Arigami, Rajmohan Murali, Richard A. Scolyer, more

Pigment Cell & Melanoma Research > 23 > 1 > 137 - 140

article

The PGF_2α receptor FP is lost in nevi and melanoma

Alex Fricke, Lindy McClelland, Glynis Scott

Pigment Cell & Melanoma Research > 23 > 1 > 141 - 143

article

UVA tanning is involved in the increased incidence of skin cancers in fair‐skinned young women

Sergio G. Coelho, Vincent J. Hearing

Pigment Cell & Melanoma Research > 23 > 1 > 57 - 63

Melanomas are the most prevalent cancers in 25–29 yr old females and compose roughly 12% of cancers in 20–40 yr old women; under the age of 40, women have a higher incidence of melanomas than do men. Within the past few decades, the alarming trend to use commercial sunlamps for cosmetic pigmentation is of particular concern, especially since 71% of those patrons are women with 50% of patrons under...

article

Melanocytes don’t always take the high road

Hun‐Way Hwang, William J. Pavan

Pigment Cell & Melanoma Research > 23 > 1 > 11 - 13

article

H19 RNA downregulation stimulated melanogenesis in melasma

Nan‐Hyung Kim, Chang‐Hoon Lee, Ai‐Young Lee

Pigment Cell & Melanoma Research > 23 > 1 > 84 - 92

A variety of factors, including ultraviolet (UV) exposure, have been implicated in the pathogenesis of melasma. However, UV‐induced hyperpigmentation usually recovers spontaneously, whereas melasma does not. Recently, we detected downregulation of the H19 gene on microarray analysis of hyperpigmented and normally pigmented skin from patients with melasma, and identified significant clinical correlations...

article

Anticipating drug resistance in the MAP kinase pathway

Ronen Marmorstein

Pigment Cell & Melanoma Research > 23 > 1 > 7 - 9

article

The Wellcome Trust Functional Genomics Cell Bank: holdings

Pigment Cell & Melanoma Research > 23 > 1 > 147 - 150

article

Keratinocytes in culture accumulate phagocytosed melanosomes in the perinuclear area

Hideya Ando, Yoko Niki, Masaki Yoshida, Masaaki Ito, more

Pigment Cell & Melanoma Research > 23 > 1 > 129 - 133

There are many techniques for evaluating melanosome transfer to keratinocytes but the spectrophotometric quantification of melanosomes incorporated by keratinocyte phagocytosis has not been previously reported. Here we describe a new method that allows the spectrophotometric visualization of melanosome uptake by normal human keratinocytes in culture. Fontana‐Masson staining of keratinocytes incubated...

article

Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4^R24C/R24C/Tyr‐Nras^Q61K mice following neonatal UVR

Elke Hacker, H. Konrad Muller, Nicholas Hayward, Paul Fahey, more

Pigment Cell & Melanoma Research > 23 > 1 > 121 - 128

To further investigate the use of DNA repair‐enhancing agents for skin cancer prevention, we treated Cdk4^R24C/R24C/Nras^Q61K mice topically with the T4 endonuclease V DNA repair enzyme (known as Dimericine) immediately prior to neonatal ultraviolet radiation (UVR) exposure, which has a powerful effect in exacerbating melanoma development in the mouse model. Dimericine has been shown to reduce the incidence...

article

Moesin/ezrin: a specific role in cell metastasis?

Dominique Lallemand, Monique Arpin

Pigment Cell & Melanoma Research > 23 > 1 > 6 - 7

article

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)

Seung‐Shick Shin, Brian A. Wall, James S. Goydos, Suzie Chen

Pigment Cell & Melanoma Research > 23 > 1 > 103 - 111

We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1‐mouse‐melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro. In addition, these clones also exhibit aggressive tumorigenic phenotypes in vivo with short latency in tumor formation in both immunodeficient and syngeneic mice. We also detected strong activation of AKT in allograft...

article

Fifteen‐year quest for microphthalmia‐associated transcription factor target genes

Yann Cheli, Mickael Ohanna, Robert Ballotti, Corine Bertolotto

Pigment Cell & Melanoma Research > 23 > 1 > 27 - 40

Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, TYRP1 and DCT genes, encoding the three enzymes involved in melanin synthesis or melanogenesis. Sixteen years after the first description of MITF, more than 40 direct MITF target genes have been described. They play a key...

article

TYRO3‐mediated regulation of MITF: a novel target in melanoma?

Udo Rudloff, Yardena Samuels

Pigment Cell & Melanoma Research > 23 > 1 > 9 - 11

article

Dormancy of metastatic melanoma

Liliana Ossowski, Julio A. Aguirre‐Ghiso

Pigment Cell & Melanoma Research > 23 > 1 > 41 - 56

Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt recurrences. Nevertheless, analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently...

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MELANOMA (368)
MELANOCYTE (78)
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PIGMENTATION (45)
MELANIN (38)
MELANOGENESIS (37)
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RNA‐SEQ (6)
SKIN PIGMENTATION (6)
SOX10 (6)
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INFONA - science communication portal

Pigment Cell & Melanoma Research

The pigmented road ahead – success through collaboration

Inducible expression of ^V600EBraf using tyrosinase‐driven Cre recombinase results in embryonic lethality

Androgen, estrogen and progesterone receptors in acquired bilateral nevus of Ota‐like macules

Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma

A colorful explanation for atrial arrhythmias

Melanoma from bench to bedside: meeting report from the 6th international melanoma congress

High molecular weight–melanoma‐associated antigen as a biomarker of desmoplastic melanoma

The PGF_2α receptor FP is lost in nevi and melanoma

UVA tanning is involved in the increased incidence of skin cancers in fair‐skinned young women

Melanocytes don’t always take the high road

H19 RNA downregulation stimulated melanogenesis in melasma

Anticipating drug resistance in the MAP kinase pathway

The Wellcome Trust Functional Genomics Cell Bank: holdings

Keratinocytes in culture accumulate phagocytosed melanosomes in the perinuclear area

Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4^R24C/R24C/Tyr‐Nras^Q61K mice following neonatal UVR

Moesin/ezrin: a specific role in cell metastasis?

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)

Fifteen‐year quest for microphthalmia‐associated transcription factor target genes

TYRO3‐mediated regulation of MITF: a novel target in melanoma?

Dormancy of metastatic melanoma

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