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Atherosclerotic lesions develop in regions of the vasculature with complex fluid shear stress (FSS) patterns. Endothelial cells (EC) in atheroprone and atheroprotected regions are exposed to low oscillatory (OS) or high unidirectional (US) shear stresses respectively. Oxidative stress and altered activity of the transcription factor Nrf2 have been shown to contribute to atherogenesis. Using in vitro...
Aims/hypothesis Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria...
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