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Atherosclerotic lesions develop in regions of the vasculature with complex fluid shear stress (FSS) patterns. Endothelial cells (EC) in atheroprone and atheroprotected regions are exposed to low oscillatory (OS) or high unidirectional (US) shear stresses respectively. Oxidative stress and altered activity of the transcription factor Nrf2 have been shown to contribute to atherogenesis. Using in vitro...
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