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Purpose: Apoptosis occurs in response to many different stimuli. We examined the induction of apoptosis by Fludara (Fludarabine phosphate) in vitro against freshly isolated B-chronic lymphocytic leukemia (B-CLL) cells and in vivo in B-CLL patients. We also studied the expression and function of CD95 (Fas/APO-1) antigen in B-CLL cells with the help of anti-Fas monoclonal antibodies (Mabs).Methods:...
The review is devoted to analysis of published and personal data on the role of the disulphide bridges of residual protein (RP) in the structuro-functional organization of chromosomal DNA. A comparative study is made of the effect of different S-S cleaving agents (2-mercaptoethanol, dithiothreitol, sodium borhydride, glutathione reductase) on natural DNA-RP complexes isolated from different cells...
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