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It was shown for the first time by computer experiments that fatty acids are strongly bound to DNA. This is consistent with the presence of free fatty acids in the specimens of DNA-bound lipids isolated from various cells. Binding of all fatty acids to the DNA minor groove is stronger than to the major groove, which is correlated with the presence of two pools of free fatty acids isolated from DNA...
The review is devoted to analysis of published and personal data on the role of the disulphide bridges of residual protein (RP) in the structuro-functional organization of chromosomal DNA. A comparative study is made of the effect of different S-S cleaving agents (2-mercaptoethanol, dithiothreitol, sodium borhydride, glutathione reductase) on natural DNA-RP complexes isolated from different cells...
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