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It is widely accepted that with the demographic shift towards an ageing population prevalence of age-related cardiovascular disease will increase. Whether cardioprotective strategies are still effective in elderly is a matter of debate. We have previously demonstrated that magnesium orotate (MO) was cardioprotective in adult rat hearts subjected to acute ischemia/reperfusion (I/R) injury. The present...
The classic enzymatic systems that contribute to the generation of reactive oxygen species (ROS) responsible for the development of endothelial dysfunction and neuropathy in diabetes are mitochondrial respiratory chain, NADPH oxidases, xanthine oxidase, and uncoupled endothelial NO synthase (eNOS). Monoamine oxidases (MAOs) are flavo-enzymes with two isoforms, A and B, located at the outer mitochondrial...