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There is a growing body of evidence pointing to the role of purinergic signaling in the development and progression of various conditions that have inflammation as a common pathogenetic denominator. The aim of the present study was to assess the involvement of P2Y11 purinergic receptors in the regulation of vascular function in aortic segments obtained using an experimental model of acute inflammation,...
It is widely accepted that with the demographic shift towards an ageing population prevalence of age-related cardiovascular disease will increase. Whether cardioprotective strategies are still effective in elderly is a matter of debate. We have previously demonstrated that magnesium orotate (MO) was cardioprotective in adult rat hearts subjected to acute ischemia/reperfusion (I/R) injury. The present...
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