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In this paper, we report our investigation on the force-induced responses of zebrafish chorion before and after being perturbed by an externally applied prescribed force. Our experimental results show that application of an external force leads to a reduction in the stiffness of the zebrafish chorion, and that variation in such a reduction is strongly influenced by the perturbation time. Our results...
The mammalian immune system consists of vital tissue microenvironments that exhibit remarkable structural complexity and dynamic cellular behaviors. It is now possible to acquire time-lapse series of multi-channel three dimensional images of multiple cell types and vasculature simultaneously, revealing dynamic events in their living tissue context. This talk will describe automated image analysis...
Summary form only given. A large amount of three-dimensional (3D) scaffolds will be needed for cell proliferation and tissue engineering applications. To meet the requirement of high throughput and low cost manufacturing, we have investigated a few of laboratory-scale fabrication methods, including i) micro contact thermal printing of electrospun nanofibers, ii) centrifugal melt spinning and iii)...
Bone remodelling in adult skeleton is a process of maintaining bone mass through combined activities of bone forming osteoblasts and bone resorbing osteoclasts. Focusing on a molecular pathway mediated by osteoprotegerin, the authors derived a mathematical formulation for molecular interactions and cellular behaviours. The authors also treated this remodelling process as a homeostatic regulator in...
MAPK cell signal transduction pathways determine the survival of the cells. If one can control this pathways, and then they will prohibit the proliferation of the cancer cells. Furthermore, they will heal the cancer smoothly. In order to attain this goal, we use lots of drugs to interact with MEK1 in MAPK, by using computer aided drug design to analyze the ligand activity of proteins in MEK1.
We present a process for fabricating a nanoscale probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Electrodes in contact with cells detected prominent spontaneous...
In this study, we designed a Cell-to-ECG forward model to simulate ischemia condition from cell level, and then defined five different ischemia locations including inferior, anterior, septal, lateral, and apex on an actual 3-D heart geometry from CT images. For simulating the early ischemia, the ion channels are adjusted through concentration and conductance. The extent of ischemia is defined with...
This research is to develop a system to allow cancer researchers as well as drug discovery people to study drug effects in situ, real-time and at "few cells" level but large cell numbers. A microelectrode array was designed and fabricated by using silicon micromachining technology. The cancer cell NCI-H460 was attached on the Au microelectrode and the high impedance sensitivity at very "few...
The repair of dense fiber-reinforced tissues poses a significant challenge for the tissue engineering community. The function of these structures is largely dependent on their architectural form, and as such, scaffold organization is an important design parameter in generating tissue analogues. To address this issue, we have recently utilized electrospinning to instill controllable fiber anisotropy...
Summary form only given. Amorphous carbon or diamond-like carbon (DLC) films have attracted much attention recently due to their good biocompatibility and have been proposed for use in blood contacting medical devices. The behavior of cultured cells is a good indicator of the surface biocompatibility and biological responses. In this study, amorphous hydrogenated carbon films were produced and a series...
We have developed a new integrated probabilistic method for cellular function prediction by using microarray gene expression profiles, in conjunction with predicted protein-protein interactions and annotations of known proteins through an integrative statistical model. Our approach is based on a novel assessment for the relationship between correlation of two genes' expression profiles and their functional...
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