The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Corporate and advanced information and database technologies make it possible to solve potential and hidden problems, such as uncertainty data interactions, disputable resolutions, unclear processes, etc. In this case, a rough set method can be used to grasp characteristics of the classified objects included in those problems. The rough set method is often used for classifying data while figuring...
In order to simulate biological processes, we use multi-agents system. However, modelling cell behavior in systems biology is complex and may be based on intracellular biochemical pathway. So, we have developed in this study a Fuzzy Influence Graph to model MAPK pathway. A Fuzzy Influence Graph is also called Fuzzy Cognitive Map. This model can be integrated in agents representing cells. Results indicate...
Riboswitches are cis-acting genetic regulatory elements within a specific mRNA, and can regulate both transcription and translation by interacting with their corresponding metabolites. Recently, more and more riboswitches were identified and investigated about their roles in regulatory functions in different species. Both of the sequence contexts and structural conformations are important characteristics...
Copy-Number Variations (CNVs) can be defined as gains or losses that are greater than 1 kbs of genomic DNA among phenotypically normal individuals. CNVs detected by microarray based approach are limited to medium or large sized ones because of its low resolution. Here we propose a novel approach to detect CNVs by aligning the short reads obtained by high-throughput sequencer to the previously assembled...
The species of the fungus (Monascus purpureus, NPUST, Taiwan) used to produce the high pigment was isolated from rice waste. Its genomic DNA was confirmed by examining the NCBI database to check this species is M. purpureus strain ATCC 36114 (Identity 100%, Gap 0%). In this study, Taguchi Method was applied to find the optimal conditions of medium composition to enhance the production of pigments...
The aim of this study is based on GM(0,N) model to evaluate the biochemical factors in preterm neonates, include growth hormone (GH), insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs) and leptin, the proteins known to be involved in the regulation of growth. And find the influence for each factor corresponding with the body mass index(BMI) and postnatal growth(PI). First, we use the...
MAPK cell signal transduction pathways determine the survival of the cells. If one can control this pathways, and then they will prohibit the proliferation of the cancer cells. Furthermore, they will heal the cancer smoothly. In order to attain this goal, we use lots of drugs to interact with MEK1 in MAPK, by using computer aided drug design to analyze the ligand activity of proteins in MEK1.
In this work, we develop a platform for assaying biomolecules involving the measurement of alternating current AC magnetoreduction of magnetic reagent mixed with a detected sample. The magnetic reagent contains magnetic nanoparticles coated with a given kind of antibody, which associates with conjugated biomolecules. Then, the biomolecules can be quantitatively detected by measuring the AC magnetoreduction...
Cell morphology is an often-utilized feature in biology and medical science because changes in the shape of a cell indicate that some abnormal alterations may have occurred within the cell. However, there is little knowledge about the relationship between phenotype and genes. In this study, for determining the genetic effect on phenotypes, we designed a new algorithm called phenotype analysis with...
During gene expression, transcription factors are unable to bind to a transcription binding site (TFBS) involved in regulation if DNA methylation has occurred at the TFBS. Methyl-CpG-binding proteins may also occupy the TFBS and prevent the functioning of a transcription factor. Thus, the methylation status of CpG sites is an important issue when trying to understand gene regulation and shows strong...
The presence of lymphocytic infiltration (LI) has been correlated with nodal metastasis and tumor recurrence in HER2+breast cancer (BC), making it important to study LI. The ability to detect and quantify extent of LI could serve as an image based prognostic tool for HER2+ BC patients. Lymphocyte segmentation in H & E-stained BC histopathology images is, however, complicated due to the similarity...
We propose an integrated framework that can simultaneously segment and register a set of medical images using a geometric active model and a pseudo-likelihood method. First, we segment given medical volume data using a fast matching and geometric deformable model and extract a surface of an object from the segmented volume data. Second, we use the hidden Markov random field model and the pseudo-likelihood...
Protein function is highly correlated with its three dimensional conformation in order to interact with others proteins, ligands, substrates, inhibitors, etc. Studies on binding site and protein function have been investigated to understand the mechanism of protein activity; therefore, protein stability and flexibility play different roles on protein functions. In this work, we propose a framework...
Intraoral radiographs have been taken to diagnose periapical lesions. Subsequent endodontic treatment needs to be evaluated quantitatively, that is often difficult due to various imaging factors as well as subjective visual interpretation. Therefore, we sought to establish an image analysis based quantitative model to evaluate endodontic treatments (40 effective and 43 noneffective cases). To normalize...
The Possibilistic Latent Variable (PLV) clustering algorithm is a powerful tool for the analysis of complex datasets due to its robustness toward data distributions of different types and its ability to accurately identify the inherent clusters within the data. The scaling coefficient in the PLV algorithm plays a key role in reducing the effects of noise, thereby improving the precision of the clustering...
We have used Quantum dots (QD) bioconjugated with Transferrin (Tf) as targeted luminescent probes to label pancreatic cancer cells, and have employed a confocal microscope to localize the distribution and track the dynamics of QD-Tf nanocomplexes. In this paper, we present our recent results on QD-Tf tracking and vesicle imaging, including quasi-real-time visualization of QD-Tf transport inside cells...
High Content Screening (HCS) is a method for analyzing large numbers of cells typically arranged in arrays. Multi-well assays and micro-pallet arrays can be used to single out and harvest cells with desired features. However, visual inspection of large time series of images, each containing hundreds of wells or tens of thousands of micro-pallets is time-consuming and prone to detection errors.We have...
Semantic Capability Description Language (SCDL) plays an important role as a common language and provides a generic format for problem formalization. In this paper we extend SCDL to include typical applications in drug discovery and development that include similarity and substructure searches, quantitative structure activity relationship modeling and in silico docking experiments.
Microarray technology is a popular and informative technique widely used in experimental molecular biology, which can produce quantitative expression measurements for thousands of genes in a single cellular mRNA sample. Analysis methods for determining significant genes are essential to extracting information from the multitude of data generated from a single microarray experiment. Raw gene expression...
Accelerating a protein folding by implementing it in a reconfigurable field programmable gate array (FPGA) is described. This paper presents a methodology for the design of a reconfigurable computing system applied to a complex problem in molecular biology: the protein folding problem. This paper employed VMD tool and force field simulation theorem based on FPGA for protein folding solution. This...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.