Wyniki wyszukiwania dla: Eleanor N. Fish

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artykuł

CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis

Darrin Gao, Lisa H. Cazares, Eleanor N. Fish

BMC Cancer > 2017 > 17 > 1 > 1-13

Background In earlier studies we have shown that CCL5 activation of CCR5 induces the proliferation and survival of breast cancer cells in a mechanistic target of rapamycin (mTOR)-dependent manner and that this is in part due to CCR5-mediated increases in glycolytic metabolism. Methods Using the MDA-MB-231 triple negative human breast cancer cell line and mouse mammary tumor virus – polyomavirus...

artykuł

Interferon‐β regulates dendritic cell activation and migration in experimental autoimmune encephalomyelitis

Leesa M. Pennell, Eleanor N. Fish

Immunology > 152 > 3 > 439 - 450

CD11c⁺ dendritic cells (DCs) exert a critical role as antigen‐presenting cells in regulating pathogenic T cells in multiple sclerosis (MS). To determine whether the therapeutic benefit of interferon‐β (IFN‐β) treatment for MS is in part influenced by IFN regulation of DC function, we examined the immunophenotype of DCs derived from IFN‐β^+/+ and IFN‐β^−/− mice using a myelin oligodendrocyte glycoprotein...

artykuł

Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation

Ben X. Wang, Earl G. Brown, Eleanor N. Fish

Virology > 2017 > 508 > C > 170-179

Influenza A virus (IAV) non-structural protein 1 (NS1) suppresses host innate immune responses by inhibiting type I interferon (IFN) production. We provide evidence that residues F103 and M106 in the CPSF4-binding domain of A/HK/1/68 [H3N2] NS1 contribute to post-transcriptional inhibition of antiviral IFN-stimulated genes (ISGs), thereby suppressing an antiviral type I IFN response. Recombinant (r)...

artykuł

Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis

Carole L. Galligan, Edward C. Keystone, Eleanor N. Fish

Journal of Autoimmunity > 2016 > 69 > C > 38-50

Rheumatoid arthritis (RA) is a systemic autoimmune disease. We previously identified a circulating cell population, fibrocytes, which is activated early in disease. As RA is characterized by the formation of autoantibodies and autoreactive T cells, which often precede symptom onset, the objective of these studies was to characterize fibrocyte activation in the context of T cell activation. Multidimensional...

rozdział

Chemokines and Cancer

Thomas T. Murooka, Sarah E. Ward, Eleanor N. Fish

Cancer Treatment and Research > Cytokines and Cancer > Basic Science Research > 15-44

artykuł

Changing oral vaccine to inactivated polio vaccine might increase mortality

Eleanor N Fish, Kate L Flanagan, David Furman, Sabra L Klein, więcej

The Lancet > 2016 > 387 > 10023 > 1054-1055

artykuł

IFN-β treatment for Ebola virus disease: Bench to bedside

Eleanor N. Fish, Stephen D.S. McCarthy, Thomas Hoenen, Donald R. Branch

Cytokine > 2015 > 76 > 1 > 77

To date there are no approved vaccines or antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in preclinical studies, differences in experimental methodologies make it difficult to compare their therapeutic effectiveness. Using an in vitro model of Ebola Zaire replication with transcription-competent virus like particles, we...

artykuł

Novel ULK1-mediated responses in interferon signaling

Diana Saleiro, Barbara Kroczynska, Swarna Mehrotra, Amit K. Verma, więcej

Cytokine > 2015 > 76 > 1 > 87

Type I Interferons (IFNs) are cytokines that exhibit important anti-tumorigenic, anti-viral and immunomodulatory functions. Yet, the precise mechanisms and sequence of events by which IFNs activate different signaling pathways required to mediate such responses remain to be fully defined. We have found that engagement of Type I IFN receptor (IFNR) activates a novel pathway, possibly involving both...

artykuł

Central Role of ULK1 in Type I Interferon Signaling

Diana Saleiro, Swarna Mehrotra, Barbara Kroczynska, Elspeth M. Beauchamp, więcej

Cell Reports > 2015 > 11 > 4 > 605-617

We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate that the function of ULK1 is required for gene transcription mediated via IFN-stimulated response elements (ISRE) and IFNγ activation site (GAS) elements and controls expression of key IFN-stimulated genes (ISGs). We identify ULK1 as an upstream...

artykuł

IFN-ß regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3

Daniel Burke, Leonidas C. Platanias, Eleanor N. Fish

Cytokine > 2014 > 70 > 1 > 41

An effective type I interferon (IFN)-mediated immune response requires the rapid expression of antiviral proteins that are necessary to inhibit viral replication and virus spread. We provide evidence that IFN-ß regulates metabolic events important for the induction of a rapid antiviral response. IFN-ß decreases the phosphorylation of AMP-activated protein kinase (AMPK), coincident with an increase...

artykuł

Circulating fibrocytes contribute to the pathogenesis of rheumatoid arthritis

Carole L. Galligan, Edward C. Keystone, Eleanor N. Fish

Cytokine > 2014 > 70 > 1 > 41

Rheumatoid arthritis (RA) is a systemic autoimmune disease resulting in joint inflammation and bone and cartilage destruction. We have identified a circulating cell population – fibrocytes – that is activated early in RA patients and mice with arthritis. As RA is characterized by autoreactive T cells, our objective was to characterize fibrocyte activation in the context of T cell activation. Using...

artykuł

CCL5–CCR5 interactions increase tumor cell metabolism to promote proliferation and invasion of breast cancer cells

Darrin F. Gao, Eleanor N. Fish

Cytokine > 2014 > 70 > 1 > 41

Tumor cells have acquired effectors of the innate immune system, including chemokines and their receptors, to facilitate invasion, migration and metastasis. While CCL5 may promote efficient anti-tumor immune responses, it is also associated with cancer progression and metastasis: CCL5 levels are high in more aggressive forms of breast cancer and is a predictor of rapid disease progression in stage...

artykuł

The influenza A virus NS1 SH2-binding domain regulates host IFN signaling responses and viral infection

Ben X. Wang, Eleanor N. Fish

Cytokine > 2014 > 70 > 1 > 42

The multifunctional non-structural protein 1 (NS1) of influenza A viruses (IAVs) inhibits IFN production and can interact with the regulatory subunit of PI3K, p85ß, through an SH2-binding domain. Given the contributions of NS1 to immune evasion, we undertook studies to examine the effects of NS1 in the context of the type I IFN signaling response. We provide evidence that expression of avian H5N1...

artykuł

Small molecule mimetics of an interferon-α receptor interacting domain

Angelica M. Bello, Lianhu Wei, Beata Majchrzak-Kita, Noruê Salum, więcej

Bioorganic & Medicinal Chemistry > 2014 > 22 > 3 > 978-985

Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features represented by the key residues Leu30, Arg33, and Asp35 in IRRP-1. Three of these compounds exhibited potential...

artykuł

Type I IFNs enhance metabolic activation to enable an antiviral response

Daniel J. Burke, Leonidas C. Platanias, Eleanor N. Fish

Cytokine > 2013 > 63 > 3 > 250

Type I IFNs induce an antiviral immune response within hours of virus infection, mediated by activation of signaling pathways downstream of the type I IFN receptor. An IFN-induced antiviral response requires both transcriptional activation of genes and the rapid translation of mRNAs into proteins that effect an antiviral response. Both these processes are energy taxing. Cognizant that IFNs activate...

artykuł

A role for CCL5 in breast cancer cell metabolism

Darrin F. Gao, Eleanor N. Fish

Cytokine > 2013 > 63 > 3 > 264

The inflammatory chemokine, CCL5, activates its cognate receptor, CCR5, to initiate a number of responses including chemotaxis, cell growth and apoptosis. We have shown that CCL5-mediated mTOR activation influences T cell chemotaxis by initiating the translation of proteins implicated in cell migration, including MMP-9 and cyclin D1. Rapid production of these proteins may prime T cells for efficient...

artykuł

Influenza A virus NS1: Regulating the IFN response through interactions with host proteins

Ben X. Wang, Eleanor N. Fish

Cytokine > 2013 > 63 > 3 > 307

The multifunctional non-structural protein 1 (NS1) of influenza A viruses inhibits interferon (IFN) production and can interact with multiple host proteins, including the regulatory subunit of PI3K, p85β, through an SH2-binding domain. Given the contribution of NS1 to immune evasion, we undertook studies to examine the effects of NS1 in the context of the type I IFN signaling response. We provide...

artykuł

Roles of Rictor/Sin1 complexes in IFN-generated responses

Surinder Kaur, Barbara Kroczynska, Bhumika Sharma, Antonella Sassano, więcej

Cytokine > 2013 > 63 > 3 > 276

There is emerging evidence that mammalian target of Rapamycin (mTOR) complexes play important roles in IFN-signaling and mRNA translation of interferon-stimulated genes (ISGs), by controlling the function of downstream effector pathways. We provide evidence that IFN-induced ISG expression is defective in cells with targeted disruption of the Rictor gene, a key component of the mTORC2 complex. Our...

artykuł

WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection

Erin Rogers, Ben X. Wang, Zhu Cui, David R. Rowley, więcej

Antiviral Research > 2012 > 96 > 2 > 158-168

The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20 ^−/− compared to ps20 ^+/+ ...

artykuł

Circulating fibrocytes contribute to the pathogenesis of collagen antibody–induced arthritis

Carole L. Galligan, Eleanor N. Fish

Arthritis & Rheumatology > 64 > 11 > 3583 - 3593

ObjectiveRheumatoid arthritis (RA) is a systemic autoimmune disease resulting in joint inflammation. Fibroblast‐like synoviocytes in affected joints are responsible for pannus formation and cytokine/chemokine production, resulting in leukocyte recruitment and bone/cartilage destruction. Previously, we identified a multipotent stem cell population of activated fibrocytes in the blood of patients with...

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