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CD11c+ dendritic cells (DCs) exert a critical role as antigen‐presenting cells in regulating pathogenic T cells in multiple sclerosis (MS). To determine whether the therapeutic benefit of interferon‐β (IFN‐β) treatment for MS is in part influenced by IFN regulation of DC function, we examined the immunophenotype of DCs derived from IFN‐β+/+ and IFN‐β−/− mice using a myelin oligodendrocyte glycoprotein...
Sex based differences in immune responses, affecting both the innate and adaptive immune responses, contribute to differences in the pathogenesis of infectious diseases in males and females, the response to viral vaccines and the prevalence of autoimmune diseases [1–5]. Indeed, females have a lower burden of bacterial, viral and parasitic infections, most evident during their reproductive years [2,6]...
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