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Activation of the lectin pathway of complement begins with the activation of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, which are bound to the recognition molecules, MBL and ficolins. MASPs are Ca 2+ -dependent dimers. Dimerization and Ca 2+ -dependent association with the recognition molecules occurs via the first 3 domains, the CUB1-EGF-CUB2 region...