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OLETF rats do not express functional CCK 1 receptors. Adult OLETF rats are hyperphagic and become obese. We examined OLETF (male and female) body weight from birth; the possible involvement of the dam in the development and maintenance of the pups’ obesity; circadian differences in nursing and maternal behavior; and the pups’ suckling abilities and initiative. OLETF and LETO (control) pups...
OLETF rats are heavier than controls from birth and they eat about 30% more shortly after weaning. This study examined how early dieting differently affects male and female long-term obesity in the OLETF model. We examined the influence of early-short term, early-long term and chronic food restriction, starting from the day of weaning (postnatal day [PND] 22), on obesity, adipocyte hypertrophy and...
One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different “depressed” lines were studied: the Flinders...
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