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The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na V 1.8 is selectively expressed in sensory neurons. It has been reported that Na V 1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus Na V 1.8 has been a promising target to treat...
Post‐translational glycosylation is one of the most abundant forms of covalent protein modification in eukaryotic cells. It plays an important role in determining the properties of proteins, and stabilizes many proteins against thermal denaturation. Protein glycosylation may establish a surface microenvironment that resembles that of unglycosylated proteins in concentrated solutions of sugars and...
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