David C. Prior

article

Development of a new ion mobility time-of-flight mass spectrometer

Yehia M. Ibrahim, Erin S. Baker, William F. Danielson, Randolph V. Norheim, more

International Journal of Mass Spectrometry > 2015 > 377 > C > 655-662

A new ion mobility spectrometer (IMS) platform was developed to improve upon the sensitivity and reproducibility of our previous platforms, and further enhance IMS–MS utility for broad ‘pan-omics’ measurements. The new platform incorporated an improved electrospray ionization source and interface for enhanced sensitivity, and providing the basis for further benefits based upon implementation of multiplexed...

article

Pulsed Multiple Reaction Monitoring Approach to Enhancing Sensitivity of a Tandem Quadrupole Mass Spectrometer

Mikhail E. Belov, Satendra Prasad, David C. Prior, William F. Danielson, more

Analytical Chemistry > 2011 > 83 > 6 > 2162 - 2171

article

High-Resolution Differential Ion Mobility Separations Using Planar Analyzers at Elevated Dispersion Fields

Alexandre A. Shvartsburg, David C. Prior, Keqi Tang, Richard D. Smith

Analytical Chemistry > 2010 > 82 > 18 > 7649 - 7655

article

Characterization of an ion mobility-multiplexed collision-induced dissociation-tandem time-of-flight mass spectrometry approach

Yehia M. Ibrahim, David C. Prior, Erin S. Baker, Richard D. Smith, more

International Journal of Mass Spectrometry > 2010 > 293 > 1-3 > 34-44

The confidence in peptide (and protein) identifications with ion mobility spectrometry time-of-flight mass spectrometry (IMS–TOFMS) is expected to drastically improve with the addition of information from an efficient ion dissociation step prior to MS detection. High throughput IMS–TOFMS analysis imposes a strong need for multiplexed ion dissociation approaches where multiple precursor ions yield...

article

An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

Erin Shammel Baker, Eric A. Livesay, Daniel J. Orton, Ronald J. Moore, more

Journal of Proteome Research > 2010 > 9 > 2 > 997 - 1006

article

Improving FAIMS Sensitivity Using a Planar Geometry with Slit Interfaces

Ridha Mabrouki, Ryan T. Kelly, David C. Prior, Alexandre A. Shvartsburg, more

Journal of the American Society for Mass Spectrometry > 2009 > 20 > 9 > 1768-1774

Differential mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) is gaining broad acceptance for analyses of gas-phase ions, especially in conjunction with largely orthogonal separation methods such as mass spectrometry (MS) and/or conventional (drift tube) ion mobility spectrometry. In FAIMS, ions are filtered while passing through a gap between two electrodes that...

article

Selection of the Optimum Electrospray Voltage for Gradient Elution LC-MS Measurements

Ioan Marginean, Ryan T. Kelly, Ronald J. Moore, David C. Prior, more

Journal of the American Society for Mass Spectrometry > 2009 > 20 > 4 > 682-688

Changes in liquid composition during gradient elution liquid chromatography (LC) coupled to mass spectrometry (MS) analyses affect the electrospray operation. To establish methodologies for judicious selection of the electrospray voltage, we monitored in real time the effect of the LC gradient on the spray current. The optimum range of the electrospray voltage decreased as the concentration of organic...

article

Selection of the optimum electrospray voltage for gradient elution LC-MS measurements

Ioan Marginean, Ryan T. Kelly, Ronald J. Moore, David C. Prior, more

Journal of The American Society for Mass Spectrometry > 2009 > 20 > 4 > 682-688

Changes in liquid composition during gradient elution liquid chromatography (LC) coupled to mass spectrometry (MS) analyses affect the electrospray operation. To establish methodologies for judicious selection of the electrospray voltage, we monitored in real time the effect of the LC gradient on the spray current. The optimum range of the electrospray voltage decreased as the concentration of organic...

article

Improving FAIMS sensitivity using a planar geometry with slit interfaces

Ridha Mabrouki, Ryan T. Kelly, David C. Prior, Alexandre A. Shvartsburg, more

Journal of The American Society for Mass Spectrometry > 2009 > 20 > 9 > 1768-1774

Differential mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) is gaining broad acceptance for analyses of gas-phase ions, especially in conjunction with largely orthogonal separation methods such as mass spectrometry (MS) and/or conventional (drift tube) ion mobility spectrometry. In FAIMS, ions are filtered while passing through a gap between two electrodes that...

article

On-line Digestion System for Protein Characterization and Proteome Analysis

Daniel López-Ferrer, Konstantinos Petritis, Natacha M. Lourette, Brian Clowers, more

Analytical Chemistry > 2008 > 80 > 23 > 8930 - 8936

article

Analytical Characterization of the Electrospray Ion Source in the Nanoflow Regime

Ioan Marginean, Ryan T. Kelly, David C. Prior, Brian L. LaMarche, more

Analytical Chemistry > 2008 > 80 > 17 > 6573 - 6579

article

Dynamically Multiplexed Ion Mobility Time-of-Flight Mass Spectrometry

Mikhail E. Belov, Brian H. Clowers, David C. Prior, William F. Danielson III, more

Analytical Chemistry > 2008 > 80 > 15 > 5873 - 5883

article

Pseudorandom Sequence Modifications for Ion Mobility Orthogonal Time-of-Flight Mass Spectrometry

Brian H. Clowers, Mikhail E. Belov, David C. Prior, William F. Danielson, more

Analytical Chemistry > 2008 > 80 > 7 > 2464 - 2473

article

Simultaneous Fragmentation of Multiple Ions Using IMS Drift Time Dependent Collision Energies

Erin Shammel Baker, Keqi Tang, William F. Danielson, David C. Prior, more

Journal of the American Society for Mass Spectrometry > 2008 > 19 > 3 > 411-419

Ion mobility spectrometry coupled with mass spectrometry (IMS-MS) was utilized to evaluate an ion collision energy ramping technique that simultaneously fragments a variety of species. To evaluate this technique, the fragmentation patterns of a mixture of ions ranging in mass, charge state, and drift time were analyzed to determine their optimal fragmentation conditions. The precursor ions were pulsed...

article

Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry

Brian H. Clowers, Yehia M. Ibrahim, David C. Prior, William F. Danielson, more

Analytical Chemistry > 2008 > 80 > 3 > 612 - 623

article

Simultaneous fragmentation of multiple ions using IMS drift time dependent collision energies

Erin Shammel Baker, Keqi Tang, William F. Danielson, David C. Prior, more

Journal of The American Society for Mass Spectrometry > 2008 > 19 > 3 > 411-419

Ion mobility spectrometry coupled with mass spectrometry (IMS-MS) was utilized to evaluate an ion collision energy ramping technique that simultaneously fragments a variety of species. To evaluate this technique, the fragmentation patterns of a mixture of ions ranging in mass, charge state, and drift time were analyzed to determine their optimal fragmentation conditions. The precursor ions were pulsed...

article

Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry

Yehia Ibrahim, Mikhail E. Belov, Aleksey V. Tolmachev, David C. Prior, more

Analytical Chemistry > 2007 > 79 > 20 > 7845 - 7852

article

Ion Mobility Spectrometry–Mass Spectrometry Performance Using Electrodynamic Ion Funnels and Elevated Drift Gas Pressures

Erin Shammel Baker, Brian H. Clowers, Fumin Li, Keqi Tang, more

Journal of the American Society for Mass Spectrometry > 2007 > 18 > 7 > 1176-1187

The ability of ion mobility spectrometry coupled with mass spectrometry (IMS-MS) to characterize biological mixtures has been illustrated over the past eight years. However, the challenges posed by the extreme complexity of many biological samples have demonstrated the need for higher resolution IMS-MS measurements. We have developed a higher resolution ESI-IMS-TOF MS by utilizing high-pressure electrodynamic...

article

Multiplexed Ion Mobility Spectrometry-Orthogonal Time-of-Flight Mass Spectrometry

Mikhail E. Belov, Michael A. Buschbach, David C. Prior, Keqi Tang, more

Analytical Chemistry > 2007 > 79 > 6 > 2451 - 2462

article

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures

Erin Shammel Baker, Brian H. Clowers, Fumin Li, Keqi Tang, more

Journal of The American Society for Mass Spectrometry > 2007 > 18 > 7 > 1176-1187

The ability of ion mobility spectrometry coupled with mass spectrometry (IMS-MS) to characterize biological mixtures has been illustrated over the past eight years. However, the challenges posed by the extreme complexity of many biological samples have demonstrated the need for higher resolution IMS-MS measurements. We have developed a higher resolution ESI-IMS-TOF MS by utilizing high-pressure electrodynamic...

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Search results for: David C. Prior

Development of a new ion mobility time-of-flight mass spectrometer

Pulsed Multiple Reaction Monitoring Approach to Enhancing Sensitivity of a Tandem Quadrupole Mass Spectrometer

High-Resolution Differential Ion Mobility Separations Using Planar Analyzers at Elevated Dispersion Fields

Characterization of an ion mobility-multiplexed collision-induced dissociation-tandem time-of-flight mass spectrometry approach

An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

Improving FAIMS Sensitivity Using a Planar Geometry with Slit Interfaces

Selection of the Optimum Electrospray Voltage for Gradient Elution LC-MS Measurements

Selection of the optimum electrospray voltage for gradient elution LC-MS measurements

Improving FAIMS sensitivity using a planar geometry with slit interfaces

On-line Digestion System for Protein Characterization and Proteome Analysis

Analytical Characterization of the Electrospray Ion Source in the Nanoflow Regime

Dynamically Multiplexed Ion Mobility Time-of-Flight Mass Spectrometry

Pseudorandom Sequence Modifications for Ion Mobility Orthogonal Time-of-Flight Mass Spectrometry

Simultaneous Fragmentation of Multiple Ions Using IMS Drift Time Dependent Collision Energies

Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry

Simultaneous fragmentation of multiple ions using IMS drift time dependent collision energies

Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry

Ion Mobility Spectrometry–Mass Spectrometry Performance Using Electrodynamic Ion Funnels and Elevated Drift Gas Pressures

Multiplexed Ion Mobility Spectrometry-Orthogonal Time-of-Flight Mass Spectrometry

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures

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