Search results for: Brian H. Clowers

Items from 1 to 20 out of 45 results

article

Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry

Cameron N. Naylor, Tobias Reinecke, Mark E. Ridgeway, Melvin A. Park, more

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 10 > 2152-2162

Using contemporary theory for ion mobility spectrometry (IMS), gas-phase ion mobilities within a trapped ion mobility-mass spectrometer (TIMS) are not easily deduced using first principle equations due to non-linear pressure changes and consequently variations in E/N. It is for this reason that prior literature values have traditionally been used for TIMS calibration. Additionally, given that verified...

article

Recommendations for reporting ion mobility Mass Spectrometry measurements

Valérie Gabelica, Alexandre A. Shvartsburg, Carlos Afonso, Perdita Barran, more

Mass Spectrometry Reviews > 38 > 3 > 291 - 320

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors...

article

Determination of Gas-Phase Ion Mobility Coefficients Using Voltage Sweep Multiplexing

Tobias Reinecke, Austen L. Davis, Brian H. Clowers

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 6 > 977-986

In a standard single averaged, drift tube ion mobility spectrometry (IMS) experiment, typically less than 1% of the ions are utilized, with the rest of the ions neutralizing on a closed ion gate or ion optic element. Though some efforts at lower pressures (e.g., 4 Torr) have been made to address this issue by concentrating ions prior to release into a drift cell, the ion current reaching the detector...

article

Interrogating Proton Affinities of Organophosphonate Species Via Atmospheric Flow Tube Mass Spectrometry and Computational Methods

Kelsey A. Morrison, Benjamin J. Bythell, Brian H. Clowers

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 7 > 1308-1320

Within trace vapor analysis in environmental monitoring, defense, and industry, atmospheric flow tube mass spectrometry (AFT-MS) can fill a role that incorporates non-contact vapor analysis with the selectivity and low detection limits of mass spectrometry. AFT-MS has been applied to quantitating certain explosives by selective clustering with nitrate and more recently applied to detecting tributyl...

article

Digital mass filter analysis in stability zones A and B

Bojana Opačić, Adam P. Huntley, Brian H. Clowers, Peter T. A. Reilly

Journal of Mass Spectrometry > 53 > 12 > 1155 - 1168

Digitally driven mass filter analysis is an advancing field. This work presents a tutorial of digital waveforms, stability diagrams, and pseudopotential well plots. Experimental results on digitally driven mass filter analysis in stability zones A and B are also shown. This work explains duty cycle manipulation of the waveforms to axially trap and eject ions from linear quadrupoles and how to change...

article

Cannabidiol modulation of antinociceptive tolerance to Δ⁹-tetrahydrocannabinol

Nicholas Z. Greene, Jenny L. Wiley, Zhihao Yu, Brian H. Clowers, more

Psychopharmacology > 2018 > 235 > 11 > 3289-3302

Rationale Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. Objective The present study compared the development of tolerance to the antinociceptive effects of THC given...

article

Characterization of alkylphosphonic acid vapors using atmospheric flow tube–ion trap mass spectrometry

Kelsey A. Morrison, Brian H. Clowers

Rapid Communications in Mass Spectrometry > 32 > 16 > 1363 - 1371

Rationale A key aspect of detecting hazardous compounds at ultra‐trace levels for processing, compliance, and clean‐up purposes involves developing methods that are not only sensitive, but also highly selective with minimal sampling effort. Atmospheric flow tube mass spectrometry (AFT‐MS) using dielectric barrier discharge ionization has emerged as a technique that combines such features for vapor...

article

Using Digital Waveforms to Mitigate Solvent Clustering During Mass Filter Analysis of Proteins

Bojana Opačić, Nathan M. Hoffman, Zachary P. Gotlib, Brian H. Clowers, more

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 10 > 2081-2085

With advances in the precision of digital electronics, waveform generation technology has progressed to a state that enables the creation of m/z filters that are purely digitally driven. These advances present new methods of performing mass analyses that provide information from a chemical system that are inherently difficult to achieve by other means. One notable characteristic of digitally driven...

article

Assessment of Dimeric Metal-Glycan Adducts via Isotopic Labeling and Ion Mobility-Mass Spectrometry

Kelsey A. Morrison, Brad K. Bendiak, Brian H. Clowers

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 8 > 1638-1649

Adduction of multivalent metal ions to glycans has been shown in recent years to produce altered tandem mass spectra with collision-induced dissociation, electron transfer techniques, and photon-based fragmentation approaches. However, these approaches assume the presence of a well-characterized precursor ion population and do not fully account for the possibility of multimeric species for select...

article

Contemporary glycomic approaches using ion mobility–mass spectrometry

Kelsey A Morrison, Brian H Clowers

Current Opinion in Chemical Biology > 2018 > 42 > C > 119-129

Characterization of complex oligosaccharides has historically required extensive sample handling and separations before analysis using nuclear magnetic resonance spectroscopy and electron impact mass spectra following hydrolysis, derivatization, and gas chromatographic separation. Advances in liquid chromatography separations and tandem mass spectrometry have expanded the range of intact glycan analysis,...

article

Stabilization of gas-phase uranyl complexes enables rapid speciation using electrospray ionization and ion mobility-mass spectrometry

Austen L. Davis, Brian H. Clowers

Talanta > 2018 > 176 > C > 140-150

Significant challenges exist when characterizing f-element complexes in solution using traditional approaches such as electrochemical and spectroscopic techniques as they do not always capture information for lower abundance species. However, provided a metal-complex with sufficient stability, soft ionization techniques such as electrospray offer a means to quantify and probe the characteristics of...

article

An open source ion gate pulser for ion mobility spectrometry

Luke Garcia, Carolyn Saba, Gabriela Manocchio, Gordon A. Anderson, more

International Journal for Ion Mobility Spectrometry > 2017 > 20 > 3-4 > 87-93

Excluding the ion source, an ion mobility spectrometer is fundamentally comprised of drift chamber, ion gate, pulsing electronics, and a mechanism for amplifying and recording ion signals. Historically, the solutions to each of these challenges have been custom and rarely replicated exactly. For the IMS research community few detailed resources exist that explicitly detail the construction and operation...

article

Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity

Stevie C. Britch, Jenny L. Wiley, Zhihao Yu, Brian H. Clowers, more

Drug and Alcohol Dependence > 2017 > 175 > C > 187-197

Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ⁹-tetrahydrocannabinol’s (THC) effects. The current study examined sex differences in CBD modulation of THC-induced antinociception, hypolocomotion, and metabolism.In Experiment 1, CBD (0, 10 or 30mg/kg) was administered 15min before THC (0, 1.8, 3.2, 5.6 or 10mg/kg), and rats were tested for antinociception and locomotion...

article

Differential Fragmentation of Mobility-Selected Glycans via Ultraviolet Photodissociation and Ion Mobility-Mass Spectrometry

Kelsey A. Morrison, Brian H. Clowers

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 6 > 1236-1241

The alternative dissociation pathways initiated by ultraviolet photodissociation (UVPD) compared with collision-induced dissociation (CID) may provide useful diagnostic fragments for biomolecule identification, including glycans. However, underivatized glycans do not commonly demonstrate strong UV absorbance, resulting in low fragmentation yields for UVPD spectra. In contrast to UVPD experiments that...

article

Enhanced Mixture Separations of Metal Adducted Tetrasaccharides Using Frequency Encoded Ion Mobility Separations and Tandem Mass Spectrometry

Kelsey A. Morrison, Brad K. Bendiak, Brian H. Clowers

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 4 > 664-677

Using five isomeric tetrasaccharides in combination with seven multivalent metals, the impact on mobility separations and resulting CID spectra were examined using a hybrid ion mobility atmospheric pressure drift tube system coupled with a linear ion trap. By enhancing the duty cycle of the drift tube system using a linearly chirped frequency, the collision-induced dissociation spectra were encoded...

article

Effects of bacterial inactivation methods on downstream proteomic analysis

Andy Lin, Eric D. Merkley, Brian H. Clowers, Janine R. Hutchison, more

Journal of Microbiological Methods > 2015 > 112 > C > 3-10

Inactivation of pathogenic microbial samples is often necessary for the protection of researchers and to comply with local and federal regulations. By its nature, biological inactivation causes changes to microbial samples, potentially affecting observed experimental results. While inactivation-induced damage to materials such as DNA has been evaluated, the effect of various inactivation strategies...

article

Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements

Spencer A. Prost, Kevin L. Crowell, Erin S. Baker, Yehia M. Ibrahim, more

Journal of The American Society for Mass Spectrometry > 2014 > 25 > 12 > 2020-2027

Applying Hadamard transform multiplexing to ion mobility separations (IMS) can significantly improve the signal-to-noise ratio and throughput for IMS coupled mass spectrometry (MS) measurements by increasing the ion utilization efficiency. However, it has been determined that fluctuations in ion intensity as well as spatial shifts in the multiplexed data lower the signal-to-noise ratios and appear...

article

Nano-LC–MS/MS of Glycopeptides Produced by Nonspecific Proteolysis Enables Rapid and Extensive Site-Specific Glycosylation Determination

John W. Froehlich, Mariana Barboza, Caroline Chu, Larry A. Lerno, more

Analytical Chemistry > 2011 > 83 > 14 > 5541 - 5547

article

Comprehensive software suite for the operation, maintenance, and evaluation of an ion mobility spectrometer

Eric James Davis, Brian H. Clowers, William F. Siems, Herbert H. Hill

International Journal for Ion Mobility Spectrometry > 2011 > 14 > 2-3 > 117-124

Scientific applications of Ion Mobility Spectrometry require the ability to easily compare data between different laboratories. Reduced mobility values attempt to provide this functionality, but no standard exists for the collection and manipulation of the raw data obtained during an IMS experiment. We have created a comprehensive software suite based on the LabVIEW programming language that can be...

article

An Efficient Data Format for Mass Spectrometry-Based Proteomics

Anuj R. Shah, Jennifer Davidson, Matthew E. Monroe, Anoop M. Mayampurath, more

Journal of the American Society for Mass Spectrometry > 2010 > 21 > 10 > 1784-1788

The diverse range of mass spectrometry (MS) instrumentation along with corresponding proprietary and nonproprietary data formats has generated a proteomics community driven call for a standardized format to facilitate management, processing, storing, visualization, and exchange of both experimental and processed data. To date, significant efforts have been extended towards standardizing XML-based...

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English (44)
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Keywords

ION MOBILITY SPECTROMETRY (4)
MASS SPECTROMETRY (4)
ION MOBILITY (3)
CANNABINOIDS (2)
DIGITAL MASS FILTER (2)
ELECTROSPRAY IONIZATION (2)
GLYCANS (2)
MATRIX-ASSISTED LASER DESORPTION/IONIZATION (2)
MULTIPLEXING (2)
PAIN (2)
SEX DIFFERENCES (2)
AMBIENT VAPOR SAMPLING (1)
BIOINFORMATICS (1)
CARBOHYDRATES (1)
CHEMICAL-SPECIATION (1)
COLLISION INDUCED DISSOCIATION (1)
COMPUTATIONAL CHEMISTRY (1)
COMPUTATIONAL PROTEOMICS (1)
DATA ANALYSIS (1)
DIELECTRIC BARRIER DISCHARGE IONIZATION (DBDI) (1)
DIGITAL WAVEFORM TECHNOLOGY (1)
DRIFT-TUBE ION MOBILITY SPECTROMETRY (1)
ENTEROBACTERIACEAE (1)
EXTENDED KINETIC METHOD (1)
FALSE POSITIVE (1)
FOURIER TRANSFORM (1)
FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY (1)
GAS-PHASE CLUSTERING (1)
GAS-PHASE ION SEPARATIONS (1)
GENDER (1)
GLYCAN SEPARATION (1)
GLYCOMICS AND IMS (1)
HADAMARD TRANSFORM (1)
IM-MS (1)
INFRARED MULTIPHOTON DISSOCIATION (1)
ION GATING (1)
ION MOBILITY CALIBRATION (1)
ION MOBILITY FUNDAMENTALS (1)
ION MOBILITY-MASS SPECTROMETRY (1)
ION TRAPPING (1)
ISOMER SEPARATIONS (1)
LABVIEW (1)
LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (1)
MASS CALIBRATION (1)
MASS MEASUREMENT ACCURACY (1)
METAL ADDUCTION (1)
METAL-GLYCAN ADDUCTS (1)
MICROBIAL INACTIVATION (1)
OLIGOSACCHARIDE (1)
OPEN SOURCE HARDWARE (1)
PEPTIDE MASS FINGERPRINTING (1)
PHOSPHONATES (1)
POROUS-GRAPHITIZED CARBON (1)
PROTEIN MASS ANALYSIS (1)
PROTEOMICS (1)
PROTON AFFINITY (PA) (1)
PSEUDOPOTENTIAL PLOTS (1)
SEDATION (1)
SENSITIVITY (1)
SOFTWARE (1)
STABILITY DIAGRAMS (1)
STABILITY ZONE A (1)
STABILITY ZONE B (1)
TRANSITION METAL-GLYCAN DIMERS (1)
TRAPPED ION MOBILITY SPECTROMETRY (1)
ULTRAVIOLET PHOTOFRAGMENTATION (1)
URANIUM SPECIATION (1)
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ACS (16)
Springer (15)
Elsevier (11)
Wiley (3)

Journal

Analytical Chemistry (13)
Journal of The American Society for Mass Spectrometry (12)
Journal of the American Society for Mass Spectrometry (4)
Analytical Biochemistry (2)
International Journal for Ion Mobility Spectrometry (2)
Journal of Proteome Research (2)
Current Opinion in Chemical Biology (1)
Drug and Alcohol Dependence (1)
International Journal of Mass Spectrometry (1)
Journal of Agricultural and Food Chemistry (1)
Journal of Mass Spectrometry (1)
Journal of Microbiological Methods (1)
Mass Spectrometry Reviews (1)
Psychopharmacology (1)
Rapid Communications in Mass Spectrometry (1)
Talanta (1)
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INFONA - science communication portal

Search results for: Brian H. Clowers

Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry

Recommendations for reporting ion mobility Mass Spectrometry measurements

Determination of Gas-Phase Ion Mobility Coefficients Using Voltage Sweep Multiplexing

Interrogating Proton Affinities of Organophosphonate Species Via Atmospheric Flow Tube Mass Spectrometry and Computational Methods

Digital mass filter analysis in stability zones A and B

Cannabidiol modulation of antinociceptive tolerance to Δ⁹-tetrahydrocannabinol

Characterization of alkylphosphonic acid vapors using atmospheric flow tube–ion trap mass spectrometry

Using Digital Waveforms to Mitigate Solvent Clustering During Mass Filter Analysis of Proteins

Assessment of Dimeric Metal-Glycan Adducts via Isotopic Labeling and Ion Mobility-Mass Spectrometry

Contemporary glycomic approaches using ion mobility–mass spectrometry

Stabilization of gas-phase uranyl complexes enables rapid speciation using electrospray ionization and ion mobility-mass spectrometry

An open source ion gate pulser for ion mobility spectrometry

Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity

Differential Fragmentation of Mobility-Selected Glycans via Ultraviolet Photodissociation and Ion Mobility-Mass Spectrometry

Enhanced Mixture Separations of Metal Adducted Tetrasaccharides Using Frequency Encoded Ion Mobility Separations and Tandem Mass Spectrometry

Effects of bacterial inactivation methods on downstream proteomic analysis

Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements

Nano-LC–MS/MS of Glycopeptides Produced by Nonspecific Proteolysis Enables Rapid and Extensive Site-Specific Glycosylation Determination

Comprehensive software suite for the operation, maintenance, and evaluation of an ion mobility spectrometer

An Efficient Data Format for Mass Spectrometry-Based Proteomics

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