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Background
Neutrophil‐related chronic inflammation (NRCI) may contribute to the pathogenesis of diabetic kidney disease (DKD). We evaluated whether blocking NRCI with low‐dose colchicine prevents DKD.
Methods
A double‐blind, randomized, placebo‐controlled study was conducted. A total of 160 patients with type 2 diabetes (T2D) and microalbuminuria (urinary albumin creatinine ratio [UACR] 30 to 300...
Pneumolysin (Ply), a major virulence factor of Streptococcus pneumoniae (S. pn), affects the immunity of host cells during infection. It has been reported that Ply is involved in S. pn standard strain D39‐induced interferon‐β (IFN‐β) expression; however, other findings suggest that recombinant Ply protein is incapable of triggering IFN‐β expression. Here, we demonstrated that purified Ply was capable...
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