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CD4+ T cells recognize peptides presented by major histocompatibility complex class II molecules (MHC‐II). These peptides are generally derived from exogenous antigens. Macroautophagy has been reported to promote endogenous antigen presentation in viral infections. However, whether influenza A virus (IAV) infection‐induced macroautophagy also leads to endogenous antigen presentation through MHC‐II...