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DNA fragmentation is a hallmark of apoptosis that occurs in a variety of cell types; however, it remains unclear whether caspase‐3 is required for its induction. To investigate this, we produced caspase‐3 knockout Chinese hamster ovary (CHO)‐K1 cells and examined the effects of gene knockout and treatment with caspase‐3 inhibitors. Okadaic acid (OA) is a potent inhibitor of the serine/threonine protein...
It has been reported that mammotropes in a rodent pituitary gland are derived from somatotropes via somatomammotropes (SMTs), cells that produce both growth hormone (GH) and prolactin (Prl). However, no studies have been done on the transdifferentiation of somatotropes in the chicken pituitary gland. In this study, in order to determine the origin of mammotropes, we studied detail property of appearance...
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