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Ligand‐dependent Cre recombinases such as the CreERT2 system allow for tamoxifen‐inducible Cre recombination. Important examples are the Cx3cr1‐CreERT2 and Sall1‐CreERT2 lines that are widely used for fate mapping and gene deletion studies of brain macrophages. Our results now show that both CreERT2 lines can exhibit a high rate of tamoxifen‐independent “leaky” excision with some reporter strains,...
Tumor‐associated macrophages (TAM) are by now established as important regulators of tumor progression by impacting on tumor immunity, angiogenesis, and metastasis. Hence, a multitude of approaches are currently pursued to intervene with TAM's protumor activities, the most advanced of which being a blockade of macrophage‐colony stimulating factor (M‐CSF)/M‐CSF receptor (M‐CSFR) signaling. M‐CSFR signaling...
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