Search results for: S. Preston

Items from 1 to 20 out of 76 results

article

Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini, more

Journal of Thrombosis and Haemostasis > 20 > 10 > 2429 - 2438

Background Prolonged recovery is common after acute SARS‐CoV‐2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS‐13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute COVID‐19. We hypothesized that VWF/ADAMTS‐13 imbalance persists in convalescence together with endothelial cell (EC) activation and angiogenic...

article

Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC‐EHRA EURObservational research programme in atrial fibrillation general long‐term registry

Vincenzo L. Malavasi, Marco Vitolo, Marco Proietti, Igor Diemberger, more

European Journal of Clinical Investigation > 52 > 7 > n/a - n/a

Background The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management. Purpose To evaluate the outcomes of patients with active or prior malignancy in a contemporary cohort of European AF patients. Methods Patients enrolled in the EURObservational Research Programme in AF General Long‐Term...

article

Impact of renal impairment on atrial fibrillation: ESC‐EHRA EORP‐AF Long‐Term General Registry

Wern Yew Ding, Tatjana S. Potpara, Carina Blomström‐Lundqvist, Giuseppe Boriani, more

European Journal of Clinical Investigation > 52 > 6 > n/a - n/a

Background Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods We utilised the ESC‐EHRA EORP‐AF Long‐Term General Registry. Outcomes were analysed according to renal function by CKD‐EPI equation. The primary endpoint was a...

article

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, more

Journal of Thrombosis and Haemostasis > 19 > 10 > 2546 - 2553

Background Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS‐CoV‐2 infection. The biological mechanisms underlying this “long COVID” syndrome remain unknown. However, autopsy studies have highlighted the key roles played by pulmonary endotheliopathy and microvascular immunothrombosis in acute COVID‐19. Objectives...

article

Job strain in nonprofit human service agencies: Job demands and job control's additive effects, and goal‐related feedback's mediating role

Mark S. Preston

Nonprofit Management and Leadership > 31 > 2 > 387 - 399

Few quantitative studies in the nonprofit literature have examined job demands' strain‐inducing impact. The classic demand‐control (DC) model predicts a positive main effect for job demands and a negative main effect for job control on job strain, respectively. However, four decades of DC model studies have uncovered modest support for this additive model. As a means of addressing both issues, the...

article

Spontaneous Relaxation of Heteroepitaxial Thin Films by van der Waals‐Like Bonding on Te‐Terminated Sapphire Substrates

Stephen M. Jovanovic, Hesham M. El‐Sherif, Nabil D. Bassim, John S. Preston

Small > 16 > 45 > n/a - n/a

Here the novel direct heteroepitaxial growth method of a 3D heteroepitaxial system is demonstrated on a 3D substrate, CdTe (111)/Al₂O₃ (0001), which forms a spontaneous vdW‐like bond at the interface, instead of the two 3D crystals being strongly bound. Despite a large lattice mismatch, the thin films are single crystals and maintain high quality due the compliance of the interface which accommodates...

article

Delaying surgery for patients with a previous SARS‐CoV‐2 infection

COVIDSurg Collaborative, James C Glasbey, Dmitri Nepogodiev, Omar Omar, more

British Journal of Surgery > 107 > 12 > e601 - e602

article

A new thrombomodulin‐related coagulopathy

Aisling M. Rehill, Roger J. S. Preston

Journal of Thrombosis and Haemostasis > 18 > 9 > 2123 - 2125

article

Molecular basis of protease‐activated receptor 1 signaling diversity

Orla Willis Fox, Roger J. S. Preston

Journal of Thrombosis and Haemostasis > 18 > 1 > 6 - 16

Protease‐activated receptors (PARs) are a family of highly conserved G protein‐coupled receptors (GPCRs) that respond to extracellular proteases via a unique proteolysis‐dependent activation mechanism. Protease‐activated receptor 1 (PAR1) was the first identified member of the receptor family and plays important roles in hemostasis, inflammation and malignancy. The biology underlying PAR1 signaling...

article

Advances in understanding the molecular mechanisms that maintain normal haemostasis

James S. O'Donnell, Jamie M. O'Sullivan, Roger J. S. Preston

British Journal of Haematology > 186 > 1 > 24 - 36

Blood clot formation to stem bleeding from an injured blood vessel arises from a complex series of cellular and biochemical events, which, when dysregulated, predispose to an increased risk of thrombosis or bleeding. Similarly, haemostatic regulation of clot growth and size is exquisitely controlled by a series of anticoagulant ‘checkpoints', that exert their inhibitory activity at distinct stages...

article

Advances in understanding the molecular mechanisms of venous thrombosis

Roger J. S. Preston, Jamie M. O'Sullivan, James S. O'Donnell

British Journal of Haematology > 186 > 1 > 13 - 23

Venous thromboembolism (VTE) represents a leading cause of global mortality, however, the determinants that contribute to thrombus development remain incompletely understood. In this review, we discuss the role of inherited abnormalities of blood coagulation in VTE pathogenesis. In addition, we also consider recent emerging data suggesting other molecular and cellular determinants may also contribute...

article

Ileoanal pouch excision – a video vignette

G. H. T. Worley, S. Preston, S. K. Clark

Colorectal Disease > 21 > 2 > 247 - 247

article

Job control's strain‐buffering effects in not‐for‐profit human service agencies: A test of the nonlinear demand‐linear control model

Mark S. Preston

Nonprofit Management and Leadership > 29 > 2 > 223 - 240

In comparison to their public and for‐profit counterparts, not‐for‐profit employees report experiencing higher work demands. Despite the harmful effects attributed to this important sector difference, few, if any, empirical studies in the not‐for‐profit literature have investigated how job‐related resources, such as control over one's job, help buffer work demands' strain‐inducing impact. The present...

article

Bundled Payments for Care Improvement in the Private Sector: A Win for Everyone

Jared S. Preston, Darleen Caccavale, Amy Smith, Lauren E. Stull, more

The Journal of Arthroplasty > 2018 > 33 > 8 > 2362-2367

To help slow the rising costs associated with total joint arthroplasty (TJA), the Centers for Medicare and Medicaid Services introduced the Bundled Payments for Care Improvement (BPCI) initiative. The purpose of this study is to report our 1-year experience with BPCI in our 2 arthroplasty surgeon private practice.In this series, a historical baseline group is compared with our first year under BPCI...

article

Does job control buffer work demands' detrimental impact on public child welfare case managers' affective well-being? Extending the nonlinear demand-linear control model

Mark S. Preston

Children and Youth Services Review > 2018 > 85 > C > 219-227

Public child welfare agencies are legally responsible for the safety, permanency, and well-being of millions of vulnerable children and youth. Fulfilling this critical societal function occurs in an occupational environment consisting of large caseloads and immense time pressures. Research demonstrates that exposure to high work demands can negatively impact employees' affective well-being. Despite...

article

Feasibility and Safety of Rotational Atherectomy in Far North Queensland: A Single Non-Surgical Centre Experience

A. Dermedgoglou, R. Reyaldeen, J. Nucifora, R. Saireddy, more

Heart, Lung and Circulation > 2018 > 27 > S2 > S450

article

A novel protein C–factor VII chimera provides new insights into the structural requirements for cytoprotective protease‐activated receptor 1 signaling

E. M. Gleeson, C. J. McDonnell, E. E. Soule, O. Willis Fox, more

Journal of Thrombosis and Haemostasis > 15 > 11 > 2198 - 2207

Summary Background Activated protein C (APC) cell signaling is largely reliant upon its ability to mediate protease‐activated receptor (PAR) 1 proteolysis when bound to the endothelial cell (EC) protein C (PC) receptor (EPCR). Furthermore, EPCR‐bound PC modulates PAR1 signaling by thrombin to induce APC‐like EC cytoprotection. Objective The molecular determinants of EPCR‐dependent cytoprotective...

article

Generating Supplier Benefits through Buyer‐Enabled Knowledge Enrichment: A Social Capital Perspective

David S. Preston, Daniel Q. Chen, Morgan Swink, Laura Meade

Decision Sciences > 48 > 2 > 248 - 287

In accordance with the tenets of social capital theory, the knowledge‐based view of the firm, and absorptive capacity theory we provide an integrative research model that sheds light on how suppliers can derive benefits from a strong relationship with key buyers. In particular, we examine three research questions that address: (i) the interrelationships among the three dimensions of buyer–supplier...

article

Participants shift response deadlines based on list difficulty during reading-aloud megastudies

Michael J. Cortese, Maya M. Khanna, Robert Kopp, Jonathan B. Santo, more

Memory & Cognition > 2017 > 45 > 4 > 589-599

We tested the list homogeneity effect in reading aloud (e.g., Lupker, Brown, & Colombo, 1997) using a megastudy paradigm. In each of two conditions, we used 25 blocks of 100 trials. In the random condition, words were selected randomly for each block, whereas in the experimental condition, words were blocked by difficulty (e.g., easy words together, etc.), but the order of the blocks was randomized...

article

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

J. P. Segal, N. S. Ding, G. Worley, S. Mclaughlin, more

Alimentary Pharmacology & Therapeutics > 45 > 5 > 581 - 592

Background Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is considered the procedure of choice in patients with ulcerative colitis (UC) refractory to medical therapy. The incidence of pouchitis is 40% at 5 years. Ten to 15% of patients with pouchitis experience chronic pouchitis. Aim To determine the efficacy of medical therapies for the treatment of chronic refractory pouchitis...

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INFONA - science communication portal

Search results for: S. Preston

Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC‐EHRA EURObservational research programme in atrial fibrillation general long‐term registry

Impact of renal impairment on atrial fibrillation: ESC‐EHRA EORP‐AF Long‐Term General Registry

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

Job strain in nonprofit human service agencies: Job demands and job control's additive effects, and goal‐related feedback's mediating role

Spontaneous Relaxation of Heteroepitaxial Thin Films by van der Waals‐Like Bonding on Te‐Terminated Sapphire Substrates

Delaying surgery for patients with a previous SARS‐CoV‐2 infection

A new thrombomodulin‐related coagulopathy

Molecular basis of protease‐activated receptor 1 signaling diversity

Advances in understanding the molecular mechanisms that maintain normal haemostasis

Advances in understanding the molecular mechanisms of venous thrombosis

Ileoanal pouch excision – a video vignette

Job control's strain‐buffering effects in not‐for‐profit human service agencies: A test of the nonlinear demand‐linear control model

Bundled Payments for Care Improvement in the Private Sector: A Win for Everyone

Does job control buffer work demands' detrimental impact on public child welfare case managers' affective well-being? Extending the nonlinear demand-linear control model

Feasibility and Safety of Rotational Atherectomy in Far North Queensland: A Single Non-Surgical Centre Experience

A novel protein C–factor VII chimera provides new insights into the structural requirements for cytoprotective protease‐activated receptor 1 signaling

Generating Supplier Benefits through Buyer‐Enabled Knowledge Enrichment: A Social Capital Perspective

Participants shift response deadlines based on list difficulty during reading-aloud megastudies

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

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