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BackgroundAllergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN), are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin‐1/CCL11,...
BackgroundDuring bacterial infections of the airways, a Th1‐profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including β‐defensins, ELR‐negative CXC chemokines, and the cathelicidin LL‐37. These are downregulated by Th2 cytokines of the allergic response. Instead, the eosinophil‐recruiting chemokines eotaxin‐1/CCL11, eotaxin‐2/CCL24,...
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