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Background
Patients with systemic mastocytosis (SM) have clinical signs of mast cell (MC) activation and increased levels of MC mediators. It is unclear whether the increased mediator levels are caused by increased numbers of tissue MCs, or whether these cells in affected individuals have a hyperactive phenotype.
Objective
To determine reactivity of the skin and the airways to directly acting mediators...
BackgroundDuring bacterial infections of the airways, a Th1‐profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including β‐defensins, ELR‐negative CXC chemokines, and the cathelicidin LL‐37. These are downregulated by Th2 cytokines of the allergic response. Instead, the eosinophil‐recruiting chemokines eotaxin‐1/CCL11, eotaxin‐2/CCL24,...
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