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The gabapentinoid pregabalin is a rapid‐acting anxiolytic and analgesic, possibly suitable in supervised opioid detoxification. However, clinicians have been cautious in using it because of its unknown addictive risk and rising number of mortalities after pregabalin self‐medication in opioid abusers. Here, we studied interactions of pregabalin and morphine on reward functions of the dopamine system...