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The gabapentinoid pregabalin is a rapid‐acting anxiolytic and analgesic, possibly suitable in supervised opioid detoxification. However, clinicians have been cautious in using it because of its unknown addictive risk and rising number of mortalities after pregabalin self‐medication in opioid abusers. Here, we studied interactions of pregabalin and morphine on reward functions of the dopamine system...
Opioid antagonist treatments reduce alcohol drinking in rodent models and in alcohol‐dependent patients, with variable efficacy across different studies. These treatments may suffer from the development of tolerance and opioid receptor supersensitivity, as suggested by preclinical models showing activation of these processes during and after subchronic high‐dose administration of the short‐acting...
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