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Abstract. A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy...
Laser-induced stress waves (LSW) and aminolevulenic acid (ALA) were used to demonstrate molecular delivery through the stratum corneum (SC). The advantage of LSW for transdermal delivery is the absence of tensile components always present in ultrasound. Thus, LSW have a high threshold of tissue damage. ALA is converted in cells to protoporphyrin IX (PP IX). PP IX fluoresces at ∼634 nm (405 nm excitation)...
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