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Abstract. Rationale: In reaction time (RT) paradigms, in which a variable preparation interval preceded the imperative stimulus, RT become shorter as a function of increasing time from the start of a trial until presentation of the imperative stimulus. The shortening of RT as the preparatory foreperiod elapses reflects increasing motor readiness; however, the underlying neurochemical mechanisms are...
The orbital prefrontal cortex (OPFC) is suggested to be part of a circuitry mediating the perception of reward and the initiation of adaptive behavioural responses. In the present study, we investigated in rats changes of goal-directed behaviour after bilateral OPFC-lesions by N-methyl-d-aspartate (NMDA) in more detail. A reaction time (RT) task was used which is sensitive to subtle changes in discriminative...
. Rationale: In reaction time (RT) paradigms, in which a variable preparation interval preceded the imperative stimulus, RT become shorter as a function of increasing time from the start of a trial until presentation of the imperative stimulus. The shortening of RT as the preparatory foreperiod elapses reflects increasing motor readiness; however, the underlying neurochemical mechanisms are still...
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