Search results for: J. Leclaire

Items from 1 to 13 out of 13 results

article

Sportbootführerschein bei Epilepsie

R. Thorbecke, J. Leclaire, C. Brandt

Zeitschrift für Epileptologie > 2016 > 29 > 3 > 173-173

article

Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment?

M. El‐Alfy, C. Deloche, L. Azzi, B.A. Bernard, more

British Journal of Dermatology > 163 > 5 > 968 - 976

Background Although low dehydroepiandrosterone (DHEA) is suspected to have a role in skin ageing, little information is available on the mechanisms potentially involved. Objectives To obtain information on androgen receptor (AR) and procollagen expression in ageing skin during DHEA treatment. Methods A placebo‐controlled, randomized, prospective study was performed with 75 postmenopausal women...

article

Pangenomic changes induced by DHEA in the skin of postmenopausal women

E. Calvo, V. Luu-The, J. Morissette, C. Martel, more

Journal of Steroid Biochemistry and Molecular Biology > 2008 > 112 > 4-5 > 186-193

The objective of this study was to explore, for the first time, the changes in the pangenomic profile induced in human skin in women treated with dehydroepiandrosterone (DHEA) applied locally.Sixty postmenopausal women participated in this phase II prospective, randomized, double-blind and placebo-controlled study. Women were randomized to the twice daily local application of 0% (placebo), 0.3%, 1%...

article

Human percutaneous absorption of a direct hair dye comparing in vitro and in vivo results: Implications for safety assessment and animal testing

J. Lademann, H. Richter, U. Jacobi, A. Patzelt, more

Food and Chemical Toxicology > 2008 > 46 > 6 > 2214-2223

Although in vitro skin absorption studies often detect small residues of applied test material in the epidermis/dermis, it is uncertain whether the residue is within the living skin. We studied the dermal absorption of a hair dye hydroxyanthraquinone–aminopropyl methyl morpholinium methosulphate (HAM) in human skin in vivo and in vitro. In vivo, skin (back and scalp) received 0.5% HAM in a commercial...

article

Novel chromatographic resolution of chiral diacylglycerols and analysis of the stereoselective hydrolysis of triacylglycerols by lipases

J.A. Rodriguez, L.D. Mendoza, F. Pezzotti, N. Vanthuyne, more

Analytical Biochemistry > 2008 > 375 > 2 > 196-208

In the present study, we propose a general and accessible method for the resolution of enantiomeric 1,2-sn- and 2,3-sn-diacylglycerols based on derivatization by isocyanates, which can be easily used routinely by biochemists to evaluate the stereopreferences of lipases in a time course of triacylglycerol (TAG) hydrolysis. Diacylglycerol (DAG) enantiomers were transformed into carbamates using achiral...

article

Critical national infrastructure reliability modeling and analysis

Stephen H. Conrad, Rene J. LeClaire, Gerard P. O'Reilly, Huseyin Uzunalioglu

Bell Labs Technical Journal > 2006 > 11 > 3 > 57 - 71

One of the top 10 priorities of the U.S. Department of Homeland Security is protection of our critical national infrastructures including power, communications, transportation, and water. This paper presents models to quantify the interdependencies of critical infrastructures in the U.S. and evaluate plans to compensate for vulnerabilities. Communications is a key infrastructure, central to all others,...

article

Gene expression profiles of three different models of reconstructed human epidermis and classical cultures of keratinocytes using cDNA arrays

B. Méhul, D. Asselineau, D. Bernard, J. Leclaire, more

Archives of Dermatological Research > 2004 > 296 > 4 > 145-156

The gene expression profiles of three different models of reconstructed human epidermis were analyzed in a comparative study using cDNA array technology. The study also included normal human subconfluent keratinocytes cultured on plastic. Arrays were custom-made and comprised 504 known genes related to cutaneous biology. The gene expression profiles of the three reconstructed epidermis models shared...

article

Functional polymers as nanoscopic building blocks

J.L. Hernandez-Lopez, R.E. Bauer, W.-S. Chang, G. Glasser, more

Materials Science & Engineering C > 2003 > 23 > 1-2 > 267-274

Polyphenylene dendrimers are introduced as polymeric building blocks-with a strictly monodisperse particle size distribution within the nanometer range-for the construction of nanostructured materials and devices. The possibility for the introduction of different functionalities in the core, the scaffold or the periphery of the dendrimers offer their use as interesting modules for photonic, electronic...

article

Industry experience with alternative methods

J. Leclaire

Toxicology Letters > 1998 > 95 > Supplement 1 > 31

article

Modulation of 33D1 expression on mature murine Langerhans cells by contact sensitizers

C. Hérouet, F. Rousset, M. Cottin, J. Leclaire

Journal of Investigative Dermatology > 1997 > 109 > 2 > 257

Epicutaneous application of highly reactive chemicals can elicit contact sensitivity reactions. Elucidation of early events in the epidermis after the capture of sensitizers by Langerhans cells (LC), and leading to the migration of LC, will allow us to develop in vitro tests predictive of the sensitizing potential of xenobiotics. The development of such discriminatory tests will be based on all...

article

The use of episkin, a reconstructed epidermis, in the evaluation of protective effect of sunscreens against chemical phototoxicity induced by UVA.

C. Cohen, R. Roguet, M. Cottin, C. Olive, more

Journal of Investigative Dermatology > 1997 > 108 > 5 > 827

Phototoxicity is a well known side effect of treatment with chlorpromazine. This adverse reaction is elicited through the UVA-induced generation of a stable toxic photoproduct. In the present study we have demonstrated a UVA-dependent decrease in the cellular viability following topical treatment of the reconstructed epidermis. Episkin with a non cytotoxic dose of chlorpromazine. It was also of...

article

The use of episkin, a reconstructed epidermis, in the evaluation of protective effect of sunscreens against chemical lipoperoxidation induced by UVA.

C. Cohen, R. Roguet, M. Cottin, C. Olive, more

Journal of Investigative Dermatology > 1997 > 108 > 5 > 827

One of the advantages of reconstructed skin or epidermis over cultures of keratinocytes in monolayer is the presence of a fully differentiated horny layer which allows the topical application of sunscreen formulations and the assessment of their protective properties.The cytotoxic effect induced by UVA (320-400 nm) was investigated using a reconstructed epidermis (Episkin) on the basis of lipoperoxide...

article

Toxicologie prédictive moléculaire et génétique Application à la détection du pouvoir sensibilisant des molécules

J.L. Garrigue, Ph. Catroux, J. Leclaire

Revue francaise d'allergologie et d'immunologie clinique > 1995 > 35 > 5 > 455-461

La capacité de prévoir très précocement les phénomènes de toxicité idiosyncrasique liés aux xénobiotiques destinés à un usage pharmaceutique ou industriel en général demeure une préoccupation constante. Dans cette revue, nous confrontons les données immunologiques récentes concernant l'hypersensibilité retardée de contact (ou eczéma de contact), exemple d'effet secondaire des xénobiotiques dans certains...

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