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In the presence of oxygen (O2), carbon monoxide (CO) is synthesised from heme by endogenous hemeoxygenases, and is a powerful activator of BKCa channels. This transduction pathway has been proposed to contribute to cellular O2 sensing in rat carotid body. In the present study we have explored the role that four cysteine residues (C820, C911, C995 and C1028), located in the vicinity of the...
Hydrogen sulfide (H2S) is produced endogenously in many types of mammalian cells. Evidence is now accumulating to suggest that H2S is an endogenous signalling molecule, with a variety of molecular targets, including ion channels. Here, we describe the effects of H2S on the large conductance, calcium-sensitive potassium channel (BKCa). This channel contributes to carotid body glomus cell excitability...
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