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Polyamines modulate many biological functions. Here we report a novel inhibitory modulation by spermine of catecholamine release by the rat carotid body and have identified the molecular mechanism underpinning it. We used molecular (RT-PCR and confocal microscopy) and functional (i.e., neurotransmitter release, patch clamp recording and calcium imaging) approaches to test the involvement of: (i) voltage-dependent...
Hydrogen sulfide (H2S) is produced endogenously in many types of mammalian cells. Evidence is now accumulating to suggest that H2S is an endogenous signalling molecule, with a variety of molecular targets, including ion channels. Here, we describe the effects of H2S on the large conductance, calcium-sensitive potassium channel (BKCa). This channel contributes to carotid body glomus cell excitability...
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