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PhoSim is an optical ray tracing Monte-Carlo simulator capable of reproducing the physical processes taking place in a tissue environment when illuminated by Near-Infrared radiation. From a macroscopic point of view this can be accomplished by the proper manipulation of the Henyey-Greenstein phase parameter g, which represents a simple and analytical solution for the fast generation of a random scattering...
The current work focuses on the Time-Resolved Optical Tomographic (TROT) modality and mainly studies the scattering process that takes place in a diffusing medium like tissue when Near-Infrared radiation propagates through it. Additionally, it handles the time filtering which is necessary to be performed on the detected photons in order to gain the anatomical information of an area under investigation...
Due to the nature of the Compton Camera operation, the detection efficiency for distributed γ-sources is strongly affected by the angular acceptance and the interaction probability of the photon for a given tracer energy. In order to overcome imposed artifacts and other deformation effects in the final image, an optimization method for the reconstruction procedure is proposed. It is based on a GEANT4/GATE...
Given the complexity of the image reconstruction procedures for Compton Camera events, especially when a 3D image is required for distributed sources in space, a simple, direct algorithmic approach is presented in this work. The developed ComptonRec package carefully handles the geometry of the conic sections to accumulate ray density distribution in a user defined voxelized volume inside the specified...
The sensitivity and the spatial resolution of a smallfield γ-Camera system based on a Position Sensitive PhotoMultiplier Tube (PSPMT) on a tomographic level are examined in this study. A cylindrical Gel-Phantom (d=40 mm, h=50mm) with cylindro-conoidal tubes and capillaries (from 64 to 640 mm3) containing water solution of 99mTc is used as a test phantom in the present work. A total of 24 projections...
A small-field portable γ-Camera system based on a Position Sensitive Photomultiplier Tube (PSPMT) has been recently developed in our Lab. This prototype is to be engaged to clinical applications for planar imaging of 99Tc-radiotracers during breast cancer operations. Among the basic requirements during data-taking operation is the absence of any distorting motion which can drastically affect the quality...
Accurate reconstruction of abnormalities inside biological tissues based on the detected temperature distribution presents a major challenge in emission thermography. The present study focuses on the relationship between the physical characteristics, such as the location and the emission power, of an embedded heat source inside an absorbing medium and the measured temperature distribution on the surface...
Actinic keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential to progress to squamous cell carcinoma (SCC). We investigated the involvement of the CDKN2A, CDKN2B and p53 genes in AK and in the progression of AK to SCC. Mutational analysis on exons 1a, 1b and 2 of the CDKN2A locus and exon 1 of the CDKN2B locus as well as allelic imbalance was performed in 26 AK specimens...
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