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We demonstrate that the signal-to-noise ratio and signal collection efficiency in evanescent waveguide-based Raman spectroscopy exceeds that in Raman microscopes. We investigate the effect of silicon-nitride waveguide geometry to further improve the performance.
We investigate the membranes of cells fixed on a photonic chip using evanescent excitation and collection of Raman signals using single-mode nano-photonic waveguides. Enhancement and selectivity of the evanescent interaction allow for selectively probing the membrane with higher efficiency than confocal microscopes.
We review possible implementations of coherent anti-Stokes Raman scattering using nanophotonic waveguide circuits. Enhancement mechanisms and limitations are discussed.
Surface-enhanced Raman spectroscopy offers a tremendous potential for intracellular sensing, because it combines fingerprint specificity with sensitive signals. However, the colloidal gold nanoparticles used for this purpose lead to strong spatiotemporal variations in intracellular SERS experiments. This unpredictable behaviour, which complicates reproducible measurements, strongly contrasts to the...
We compare the performance of the nano-photonic waveguide based evanescent Raman sensors and a typical the confocal microscope. For 1 cm long strip silicon nitride waveguides, we theoretically expect more than 500 times higher signal compared to the confocal microscopic systems. The results of our preliminary measurements indicate at least 50 times higher signal. For slotted waveguides, the preliminary...
Lab-on-chip approaches, based on CMOS-compatible silicon nitride photonic waveguides, may have a large potential for Raman spectroscopy. The role of various resonant mechanisms to enhance the Raman signal is discussed.
This review is devoted to pharmacological applications of principles of release from capsules to overcome the membrane barrier. Many of these principles were developed in the context of polymeric multilayer capsule membrane modulation, but they are also pertinent to liposomes, polymersomes, capsosomes, particles, emulsion-based carriers and other carriers. We look at these methods from the physical,...
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