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Background The objective of this study was to measure myocardial blood flow (MBF) in humans using 99mTc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT). Methods Dynamic SPECT using 99mTc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction...
Coronary steal (CS) is a physiological process that induces absolute decrease in blood flow in collateralized myocardium compared to resting flow during coronary vasodilation due to redistribution of blood away from collateral-dependent myocardium. Although, CS has been well known for decades, there are very few noninvasive perfusion studies in humans that quantitatively predict the existence of CS...
The primary goal of this project is to implement the iterative statistical image reconstruction algorithm, in this case maximum likelihood expectation maximum (MLEM) used for dynamic cardiac single photon emission computed tomography, on Spark/GraphX. This involves porting the algorithm to run on large-scale parallel computing systems. Spark is an easy-toprogram software platform that can handle large...
Simultaneous imaging systems combining positron emission tomography (PET) and magnetic resonance imaging (MRI) have been actively investigated. A PET/MR imaging system (GE Healthcare) comprised of a time-of-flight (TOF) PET system utilizing silicon photomultipliers (SiPMs) and 3-tesla (3T) MRI was recently installed at our institution. The small-ring (60 cm diameter) TOF PET subsystem of this PET/MRI...
Myocardial perfusion imaging (MPI) has historically been and continues to be primarily performed using single photon emission computed tomography (SPECT). However, dynamic MPI is the domain of cardiac positron emission tomography (PET), due to its intrinsically higher sensitivity and ring scanner geometry that allows stationary tomographic acquisition, which circumvent limitations typical SPECT scanners...
Modeling of data from a dynamic acquisition is complicated by the combination of camera motion, organ motion, and the time-varying nature of the radionuclide distribution being imaged which results in inconsistent projection data sets. Our approach is to estimate the time varying radionuclide distribution directly from projection data. Entire tomographic slices or volumes are represented by a multiresolution...
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