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Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation and chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of chronic itch induced by poison ivy. However, how IL‐33/ST2 signaling in the spinal cord potentially mediates chronic itch remains elusive. Here, we determined that St2−/− substantially reduced scratching behaviors...
The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. However, the contribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated directly. Combining primary sensory neuron-specific GCaMP3 imaging with a trigeminal neuropathic pain model,...
This study investigated the effect of intracerebroventricular (ICV) administration of the angiotensin AT1 receptor antagonist losartan on the natriuresis, pressor effect, and the mitogen-activated protein kinases (MAPK) activity in the rostroventrolateral medulla (RVLM) caused by ICV injection of either angiotensin II (ANG II) or carbachol. Losartan (20μg) was infused into the lateral ventricle before,...
The aim of the present study was to determine the protective effect of peanut shell extract (EPS) on rats with acute renal failure(ARF)and possible mechanism of protection. Acute renal failure was induced by glycerol , which was injected intramuscularly in rats. Healthy male SD rats were randomly divided into 4 groups: ARF + NS group, ARF + EPS group, NS + NS group and NS + EPS group. The level of...
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