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Background Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed. Methods CCK-8 and colony formation assay were used to investigate the cell growth. Flow cytometry analysis was used to evaluate the cell cycle and cell apoptosis. The peroxide-sensitive...
Bacillary dysentery is an important infectious disease caused by shigella dysenteriae. Here, we characterized the dynamic temporal trend of bacillary dysentery, and identified climate-related risk factors and their roles in bacillary dysentery transmission in Harbin city, China. A database is integrated monthly climate factors and incidence rates of Harbin city from 1986 to 1990. In this study, three...
Sonodyanmic Therapy (SDT) is a new type of cancer therapy and has attracted lots of research attention recently. In this article, we present how nano-formulation helped SL052 to form a water soluble sono/photo-sensitize nanoparticle (SL052-NPs) for cancer treatment. The nanostructure formation encapsulates SL052 and greatly improves the SL052 physicochemical properties without modifying its chemical...
Due to their high quantum yields of singlet oxygen and excellent light-induction attributes, hypocrellins have recently received much research attention. Hypocrellins, including hypocrellin A (HA) and hypocrellin B (HB), have relatively low absorption in the phototherapeutic window (600-900 nm) due to their longest wavelength absorbance band at 584 nm. To solve this problem, amino groups are introduced...
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