Search results for: M Dawood

Items from 1 to 20 out of 112 results

article

Recent advances on quinoxalines as target‐oriented chemotherapeutic anticancer agents through apoptosis

Mohamed S. Nafie, Shaima H. Kahwash, Magdy M. Youssef, Kamal M. Dawood

Archiv der Pharmazie > 357 > 9 > n/a - n/a

The current review outlines all possible recent synthetic platforms to quinoxaline derivatives and the potent stimulated apoptosis mechanisms targeted by anticancer therapies. The currently reported results disclosed that quinoxaline derivatives had promising anticancer potencies against a wide array of cancer cell lines, better than the reference drugs, through target inhibition. This review summarizes...

article

Development of a validated HPTLC‐bioautographic method for evaluation of aromatase inhibitory activity of plant extracts and their constituents

Hend M. Dawood, Eman Shawky, Hala M. Hammoda, Aly M. Metwally, more

Phytochemical Analysis > 33 > 1 > 115 - 126

Introduction Aromatase is a CYP450 enzyme that catalyses the conversion of androgens into oestrogens, where the decrease in the production of oestrogens aided by aromatase inhibitors is considered a target in post‐menopausal breast cancer therapy. TLC‐bioautography is a technique employed for combining chromatographic separations on TLC plates with bioassays. This is the first report to evaluate...

article

Synthesis and antiviral screening of 2‐(propylthio)‐7‐substituted‐thiazolo[5,4‐d]pyrimidines as anti‐bovine viral diarrhea virus agents

Wahid M. Basyouni, Samir Y. Abbas, Khairy A. M. El‐Bayouki, Reham M. Dawood, more

Journal of Heterocyclic Chemistry > 58 > 9 > 1766 - 1774

7‐Chloro‐2‐(propylthio)thiazolo[5,4‐d]pyrimidine 4 was prepared and used as a precursor for synthesizing new derivatives of thiazolo[5,4‐d]pyrimidine through the nucleophilic displacement of the chlorine atom by different types of amino derivatives. Reaction of compound 4 with primary and secondary amines produced the corresponding substituted amino derivatives. Reaction of 4 with hydrazine hydrate...

article

Longitudinal shear in composite deck slabs using corrugated steel sheets

Hakim S. M. Alkurayshi, Adnan K. Jawad, Alaa M. Dawood, Ahmed Hakim S.

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska > 2021 > Vol. 30, No. 3 > 411--423

Profile deck steel sheets are used in composite deck slabs. These sheets are standard in dimensions and shapes besides they are supplied with embossments and indentations. Such sheets are not available in Iraqi markets nowadays therefore people used another type of sheets which are corrugated without embossments or indentations in very wide range. This study covers the use of such sheets in composite...

article

Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts

Kamal M. Dawood, Kotohiro Nomura

Advanced Synthesis & Catalysis > 363 > 8 > 1970 - 1997

This review article summarizes reports for Z‐selective olefin metathesis reactions by molybdenum, tungsten, ruthenium, and vanadium catalysts. It is clearly demonstrated that the ligand modifications play essential roles in achieving the stereospecific olefin metathesis reactions. In particular, Mo‐ and W‐alkylidene based complex catalysts having pyrrolide‐aryloxide [or bis(aryloxide)] were highly...

article

Front Cover Picture: Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts (8/2021)

Kamal M. Dawood, Kotohiro Nomura

Advanced Synthesis & Catalysis > 363 > 8 > 1969 - 1969

The front cover picture, designed by K. Nomura and K. M. Dawood illustrates the basic mechanism for Z‐selective (cis‐specific) olefin metathesis by molybdenum, ruthenium and vanadium catalysts. The review includes reports for transition metal catalyzed Z‐selective olefin metathesis reactions (EROCM, CM, ROMP, and RCM) applied for organic synthesis and polymer synthesis. The review also includes basic...

article

Facile access to some new 3,3′‐bipyrazole‐ester derivatives utilizing bis‐hydrazonoyl chlorides

Kamal M. Dawood, Abdel‐Zaher A. Elassar, Othman A. Al‐Fulaij

Journal of Heterocyclic Chemistry > 57 > 1 > 370 - 376

The 1,3‐dipolar cycloaddition reaction of bis‐hydrazonoyl chlorides with ethyl propiolate and dimethyl acetylenedicarboxylate afforded diethyl 1,1′‐aryl‐3,3′‐bipyrazole‐4,4′‐dicarboxylate and tetramethyl 1,1′‐diaryl‐3,3′‐bipyrazole‐4,4′,5,5′‐tetracarboxylate esters, respectively. Heating the latter two compounds with a mixture of HCl/AcOH furnished the same product: 3,3′‐bipyrazole‐5,5′‐dicarboxylic...

article

A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice

Reham M. Dawood, Rehab I. Moustafa, Tawfeek H. Abdelhafez, Reem El-Shenawy, more

BMC Infectious Diseases > 2019 > 19 > 1 > 1-11

Background Although DAAs hold promise to significantly reduce rates of chronic HCV infections, its eradication still requires development of an effective vaccine. Prolonged T cell responses and cross neutralizing antibodies are ideal for vaccination against the infection. We aimed to design and synthesize a 6 multi epitope peptide vaccine candidate and provide evidence for production of extended cellular...

article

Exogenous hydrogen sulfide reduces cadmium uptake and alleviates cadmium toxicity in barley

Man-Man Fu, M. Dawood, Nian-Hong Wang, Feibo Wu

Plant Growth Regulation > 2019 > 89 > 2 > 227-237

Greenhouse hydroponic experiments were conducted to evaluate the ameliorative effects of NaHS, a donor of hydrogen sulfide (H₂S), on different levels of cadmium (Cd) stress in barley seedlings. The results showed that Cd stress dramatically reduced plant biomass, chlorophyll and soluble protein contents. Exogenous application of H₂S significantly alleviated Cd-induced growth inhibition and reductions...

article

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Kamal M. Dawood

Journal of Heterocyclic Chemistry > 56 > 6 > 1701 - 1721

Bis‐thiourea derivatives have distinguished synthetic potentialities. They are interesting substrates for construction of various classes of heterocycles, such as thiazoles, thiadiazoles, imidazoles, bis‐thiazoles, bis‐thiadiazoles, and fused heterocyclic systems. The current review is concerned on disclosing the synthetic and research applications of bis‐thioureas that were reported in the literature...

article

Bond behavior of NiTiNb SMA wires embedded in CFRP composites

M. El‐Tahan, M. Dawood

Polymer Composites > 39 > 10 > 3780 - 3791

This article summarizes the details of an experimental and analytical program that was conducted to study the bond behavior between nickel‐titanium‐niobium shape memory alloy wires and fiber reinforced polymer composites. Understanding this bond behavior will facilitate the design of composite systems that are fabricated using both materials and which would exhibit unique properties that cannot be...

article

Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors

Hend M. Dawood, Reham S. Ibrahim, Eman Shawky, Hala M. Hammoda, more

Journal of Ethnopharmacology > 2018 > 224 > C > 359-372

Aromatase enzyme (CYP19) is widely known as a critical target protein for treating hormone-dependent breast cancer. Natural products from traditional medicinal plants continue to be an active source of aromatase inhibitors. Meanwhile, high cost of experimental work and low hit rate associated with HTS have stimulated the implementation of in-silico virtual screening to resolve these pitfalls, where...

article

Evaluation of existing provisions for design of “pinned” column base-plate connections

F. Kavoura, B. Gencturk, M. Dawood

Journal of Constructional Steel Research > 2018 > 148 > C > 233-250

Low-rise metal buildings are used in all geographic locations, including high seismicity regions. In the design of low-rise metal building systems, column base connections are commonly modeled as pinned supports with no rotational stiffness or moment capacity. However, past studies have indicated that base connections, which are designed as pinned supports, exhibit a non-negligible level of rotational...

article

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells

Mohammed A. El-Magd, Sara F. Khalifa, Faisal Abdulrahman A. Alzahrani, Abdelnaser A. Badawy, more

Biomedicine & Pharmacotherapy > 2018 > 105 > C > 813-823

β-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer’s disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a large verity of neural subtypes. However, this neuroprotective effect was not studied on human olfactory bulb neural...

article

Hepatitis C virus serologic relapse after treatment with direct-acting antivirals is dependent on viral RNA levels in peripheral blood mononuclear cells and the grade of liver cirrhosis

Mohamed Darwish Ahmed Abd Alla, Mostafa Kamel El Awady, Reham M. Dawood, Mostafa Abdelaziz Elhawary, more

Archives of Virology > 2018 > 163 > 10 > 2765-2774

The disappearance of hepatitis C virus (HCV) from serum and tissues for 12 weeks after the end of treatment (EOT) with direct-acting antivirals (DAAs) is known as a “sustained virologic response” (SVR) and occurs more frequently in non-cirrhotic patients than in cirrhotic patients. In this study, we evaluated the outcome of HCV treatment with sofosbuvir (SOF) plus ledipasvir (LDV) at both EOT and...

article

Immunological interaction between Giardia cyst extract and experimental toxoplasmosis

D. S. Ashour, A. E. Saad, L. M. Dawood, Y. Zamzam

Parasite Immunology > 40 > 1 > n/a - n/a

Toxoplasmosis is mostly associated with other intestinal parasitic infections especially Giardia due to shared mode of peroral infection. Toxoplasma and Giardia induce a strong T‐helper 1‐ immune response. Our aim was to induce a protective immune response that results in significant impact on intestinal and extra‐intestinal phases of Toxoplasma infection. This study was conducted in experimental...

article

Efficient direct formic acid fuel cell (DFAFC) anode of nano-sized palladium complex: High durability and activity origin

Gumaa A. El-Nagar, Kamal M. Dawood, Mohamed S. El-Deab, Bahgat E. Al-Andouli

Applied Catalysis B: Environmental > 2017 > 213 > C > 118-126

The low stability of Pd-based catalysts extremely obstructs their applied application in the direct formic acid fuel cells (DFAFCs). Herein, a novel nano-sized palladium-complex (nano-Pd_complex) with outstanding performance (activity and durability) for DFAFCs anodic reaction (Formic acid oxidation; FAO) compared to the commercial Pd-based catalysts is introduced. Morphologically, nano-sized Pd-complex...

article

Visualized strategy for predicting buildings energy consumption during early design stage using parametric analysis

E. Elbeltagi, H. Wefki, S. Abdrabou, M. Dawood, more

Journal of Building Engineering > 2017 > 13 > Complete > 127-136

Recently, there has been a high level of demand for sustainable design of buildings construction. The catalysts for such demand are rising energy costs and increasing environmental concerns. Therefore, it is important to evaluate building energy consumption, which is the key problem of building energy saving. There is a need for a reliable energy simulation model to predict buildings energy consumption...

chapter

Assay of IP mobility management in SDN based mobile network architecture

M Dawood, W Fuhrmann, B V Ghita

2017 Internet Technologies and Applications (ITA) > 69 - 74

2017 Internet Technologies and Applications (ITA)

The evolution towards mobile networks flat architecture entreat a key-role for IP mobility management in providing the ubiquitous always-on network access services. This paper provides prospects for efficient mobility management in SDN plus mobile network architecture and describe important call control flows in inter system handover scenario. Distribution of gateway function approach has been followed...

article

Synthesis of Pyrazolo[1,5‐a][1,3,5]triazine, Pyrazolo[1,5‐a]pyrimidine, and Imidazo[1,2‐b]pyrazole Derivatives Based on Imidazo[2,1‐b]thiazole Moiety

Kamal M. Dawood, Samia M. Sayed, Mohamed A. Raslan

Journal of Heterocyclic Chemistry > 54 > 4 > 2405 - 2416

3(5)‐Aminopyrazole derivative (6) has been synthesized by the reactions of the versatile unreported 2‐cyano‐N′‐(1‐(3‐methyl‐6‐phenylimidazo[2,1‐b]thiazol‐2‐yl)ethylidene)acetohydrazide (3) with phenyl isothiocyanate in KOH/DMF solution followed by reaction with methyl iodide and hydrazine hydrate. Reaction of compound 6 with some 1,3‐dicarbonyl compounds yielded pyrazolo[1,5‐a]pyrimidine derivatives...

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INFONA - science communication portal

Search results for: M Dawood

Recent advances on quinoxalines as target‐oriented chemotherapeutic anticancer agents through apoptosis

Development of a validated HPTLC‐bioautographic method for evaluation of aromatase inhibitory activity of plant extracts and their constituents

Synthesis and antiviral screening of 2‐(propylthio)‐7‐substituted‐thiazolo[5,4‐d]pyrimidines as anti‐bovine viral diarrhea virus agents

Longitudinal shear in composite deck slabs using corrugated steel sheets

Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts

Front Cover Picture: Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts (8/2021)

Facile access to some new 3,3′‐bipyrazole‐ester derivatives utilizing bis‐hydrazonoyl chlorides

A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice

Exogenous hydrogen sulfide reduces cadmium uptake and alleviates cadmium toxicity in barley

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Bond behavior of NiTiNb SMA wires embedded in CFRP composites

Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors

Evaluation of existing provisions for design of “pinned” column base-plate connections

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells

Hepatitis C virus serologic relapse after treatment with direct-acting antivirals is dependent on viral RNA levels in peripheral blood mononuclear cells and the grade of liver cirrhosis

Immunological interaction between Giardia cyst extract and experimental toxoplasmosis

Efficient direct formic acid fuel cell (DFAFC) anode of nano-sized palladium complex: High durability and activity origin

Visualized strategy for predicting buildings energy consumption during early design stage using parametric analysis

Assay of IP mobility management in SDN based mobile network architecture

Synthesis of Pyrazolo[1,5‐a][1,3,5]triazine, Pyrazolo[1,5‐a]pyrimidine, and Imidazo[1,2‐b]pyrazole Derivatives Based on Imidazo[2,1‐b]thiazole Moiety

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