Journal of Heterocyclic Chemistry

Items from 1 to 20 out of 2,382 results

article

Ag Loaded on SiO₂ as an Efficient and Recyclable Heterogeneous Catalyst for the Synthesis of Chloro‐8‐substituted‐9H‐purines

Suresh Maddila, Jignesh Valand, Harinarayana Bandaru, Kotaiah Yalagala, more

Journal of Heterocyclic Chemistry > 53 > 1 > 319 - 324

Ag support on silica has been used as an effective heterogeneous catalyst for the facile synthesis of chloro‐8‐substituted‐9H‐purine derivatives via the one‐pot reaction of 6‐chloro‐pyrimidines and substituted acids. The title compounds were formed as excellent yields with short reaction time under eco‐friendly conditions. The prepared catalyst (Ag/SiO₂) can be reused for a number of times with insignificant...

article

Synthesis and Antitumor Activity Evaluation of Some Novel‐Fused and Spiro Heterocycles Derived from a 2(3H)‐Furanone Derivative

Wael S. I. Abou‐Elmagd, Ahmed I. Hashem

Journal of Heterocyclic Chemistry > 53 > 1 > 202 - 208

2(3H)‐furanone was fused with methyl‐4‐aminobenzoate followed by hydrazinolysis to give the acid hydrazide derivative . Treatment of with carbon disulfide gave 4‐amino‐5‐mercapto‐3‐substituted triazole derivative . The presence of mercapto and amino groups adjacent to each other in compound made it valuable key precursor for the formation of fused and spiro heterocycles. Ring transformation of...

article

Natural Product‐Mimetic Scaffolds with Privileged Heterocyclic Systems: Design, Synthesis, and Evaluation of Antioxidant Activity of Quinazoquinobenzothiazinones

Kshitija Sharma, Sarita Khandelwal, R. M. Samarth, Mahendra Kumar

Journal of Heterocyclic Chemistry > 53 > 1 > 220 - 228

Structurally diverse quinazolinoquinolinobenzothiazinones based on rutaecarpine structural framework with hybrid structural features of three medicinally privileged heterocyclic systems has been synthesized as natural product‐mimetic scaffolds involving the use of multi‐step reaction sequences. The synthesized quinazolinoquinolinobenzothiazinones have been evaluated for their antioxidant and radical...

article

Synthesis of Cycloalk[b]indole Bearing Spiropiperidine Derivatives

Cevher Gündoğdu Hızlıateş, Sibel Gülle, Yavuz Ergün

Journal of Heterocyclic Chemistry > 53 > 1 > 249 - 254

The novel heterocyclic compounds that have cycloalk[b]indole moiety bearing spiropiperidinone and spiropiperidinedione (, , , , , , , and ) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide.

article

Synthesis and Properties of Photochromic Diarylethenes Bearing Thiazole Moiety

Tiesheng Hu, Zhipeng Li, Tingting Wang, Heping Zeng

Journal of Heterocyclic Chemistry > 53 > 1 > 109 - 116

Four new diarylethene derivatives based on thiophene or thiazole moieties were designed and synthesized, and the structures of compounds and were determined by single‐X‐ray diffraction analysis. All of these compounds showed reversible photochromic reactions and notable fluorescence photo‐switches in solution. Furthermore, diarylethenes and also showed good photochromism in single crystal phase...

article

Synthesis and Biological Activities of Novel 6‐Alkylamino‐11,12‐dihydro‐11‐arylbenzo[c]phenanthridine Derivatives

Min Zhang, Li Liu, Huifeng Xiao, Ting Zhao, more

Journal of Heterocyclic Chemistry > 53 > 1 > 234 - 240

A series of novel benzo[c]phenanthridine derivatives and bearing an alkylamino side chain at their 6‐position were synthesized. All of the target compounds were confirmed by ¹H NMR, ¹³C NMR, and HRMS, and some of them were also characterized by IR and ¹⁹F NMR. The preliminary bioassays showed that the target compounds displayed fungicidal activities; for example, compound showed 60.0% and 70.0%...

article

Synthesis and Molecular Docking Studies of Novel 2‐Phenyl‐4‐Substituted Oxazole Derivatives as Potential Anti‐cancer Agents

Ahmed O. H. El‐Nezhawy, Ahmad Farouk Eweas, Mohamed A. A. Radwan, Tarek B. A. El‐Naggar

Journal of Heterocyclic Chemistry > 53 > 1 > 271 - 279

A novel series of 2,4‐disubstituted oxazole derivatives were synthesized, screened for their anti‐tumor activity against three cell lines MCF‐7, TK‐10, and UACC‐62. Molecular docking study was carried out against epidermal growth factor receptor. A new series of 2‐phenyl‐4‐substituted oxazole derivatives were synthesized. A series of chiral α‐amino acid derivatives were synthesized by coupling various...

article

One‐Pot Synthesis of Some Dynamic 2‐Substituted Benzoxazinones and Their Corresponding Qinazolinones of Anticipated Biological Activity

Maher A. El‐Hashash, Mohamed E. Azab, Jehan M. Morsy

Journal of Heterocyclic Chemistry > 53 > 1 > 95 - 101

Reactions of 6‐bromo‐2‐isopropyl‐4(3H)‐3,1‐benzoxazin‐4‐one toward mono‐ and di‐dentate nitrogen nucleophiles, e.g. primary aliphatic and aromatic amines, 1,2‐phenylenediamine, hydrazine hydrate, and formamide, have been investigated and afford the corresponding quinazolinones which are expected to have some interesting biological activity. The behavior of 3, 1‐benzoxazin‐4‐one toward active methylene...

article

Csp²–O and C–C Bond Formation via Pd‐Catalyzed Coupling Reaction of 2,4‐Dichloroquinazoline

Alka Sharma, Vijay Luxami, Kamaldeep Paul

Journal of Heterocyclic Chemistry > 53 > 1 > 241 - 248

An efficient palladium‐catalyzed C–O and subsequent C–C bond formation of 2,4‐dichloroquinazoline have been described. The designed strategy results in the synthesis of novel 2‐arylated quinazolin‐4‐ones framework with various aryl/heteroaryl boronic acids in moderate to good yields along with 2,4‐diarylated quinazolines. This methodology offers a direct transformation of aryl halides to aryl alcohols/ketone...

article

Synthesis and Characterization of Bisimidazoles, Bistriazoles, Bisthiadiazoles, and Bisthiazoles from Novel Bishydrazonoyl Dichlorides

Abdelwahed R. Sayed, Sobhi M. Gomha, Thoraya A. Farghaly

Journal of Heterocyclic Chemistry > 53 > 1 > 255 - 262

We have synthesized a number of bisimidazoles, bistriazoles, and bisthiadiazoles derivatives based on new bishydrazonoylchlorides. Structures of the final products were elucidated by elemental analysis and spectral data.

article

Synthesis and Biological Activity of Ethyl 4‐Alkyl‐2‐(2‐(substituted phenoxy)acetamido)thiazole‐5‐carboxylate

Wenyan Mo, Yanxia Shi, Junbo He, Baoju Li, more

Journal of Heterocyclic Chemistry > 53 > 1 > 183 - 187

A series of novel ethyl 4‐(methyl or trifluoromethyl)‐2‐(2‐(substituted phenoxy)acetamido)thiazole‐5‐carboxylates and were synthesized, and their structures were confirmed by IR, ¹H‐NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds , , and , the...

article

Design, Synthesis and Evaluation of Antibacterial Effects of a New Class of Piperazinylquinolone Derivatives

Ali Darehkordi, Mahin Ramezani, Fariba Rahmani, Mahnaz Ramezani

Journal of Heterocyclic Chemistry > 53 > 1 > 89 - 94

Pentafluoropyridine derivatives and cyanuric chloride were used for the synthesis of new piperazinylquinolone derivatives. These reactions provided N‐fluoropyridiyl and N‐cyanoryl chloride piperazinylquinolone derivatives in good yields. Synthesized compounds were evaluated for their antibacterial activities. These compounds displayed good to excellent antibacterial activities.

article

Regioselective and Stereoselective Synthesis of Pyridine‐Fused Benzoxepine Derivatives by Intramolecular Reductive Heck Cyclization [1]

Shovan Mondal, Sudarshan Debnath

Journal of Heterocyclic Chemistry > 53 > 1 > 80 - 88

An efficient method for the synthesis of 6,11‐dihydro[2]benzoxepino[4,3‐b]pyridine derivatives via Pd(0) catalyzed intramolecular reductive Heck cyclization is reported. The method offers the regioselective and stereoselective synthesis of highly functionalized pyridine‐fused benzoxepine derivatives in 75–85% yields under mild conditions. Chemoselective Sonogashira coupling is utilized for the synthesis...

article

Synthesis of 2‐Phenylquinoline and its Derivatives by Multicomponent Reaction of Aniline, Benzylamine, Alcohols, and CCl₄ Catalyzed by FeCl₃·6H₂O

Ravil Khusnutdinov, Alfiya Bayguzina, Rishat Aminov, Usein Dzhemilev

Journal of Heterocyclic Chemistry > 53 > 1 > 144 - 146

2‐Phenylquinolines, 2‐phenyl‐3‐methyl‐quinolines, and 2‐phenyl‐3‐ethylquinolines were synthesized in high yields (78–90%) by the reaction of aniline, benzylamine, aliphatic alcohols (ethanol, n‐propanol, n‐butanol), and CCl₄ catalyzed by FeCl₃·6H₂O in tetrachloromethane.

article

A Systematic Study on the Synthesis of n‐Butyl Substituted 8‐Aminoquinolines

Ahmet Koseoglu, Turan Gul, Ali Ersin Acar

Journal of Heterocyclic Chemistry > 53 > 1 > 263 - 270

A systematic study on the synthesis of 8‐aminoquinoline derivatives with an n‐butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner–von Miller variation were used to obtain most of the quinoline ring except for the 2‐butyl‐8‐aminoquinolines and 4‐butyl‐8‐aminoquinolines where the commercially available methylquinoline derivatives were used as...

article

Synthesis of Novel Indolo‐Spirocyclic Compounds

Mardia T. El‐Sayed, Kazem Mahmoud, Andreas Hilgeroth, Issa M. I. Fakhr

Journal of Heterocyclic Chemistry > 53 > 1 > 188 - 196

In the present work, we succeeded to synthesize the novel indolo‐spirocyclic compounds ( and ) via electrophilic condensation reactions of indoles with carbonyl compounds including different types of ketones, for example, heteroacetyl ketones (3‐acetylindole and 3‐acetylpyridine), cyclohexanone, isatin, cyclohexane‐1,4‐dione, whereas an attempt to prepare the spirocyclic failed. This new idea will...

article

Convenient Synthesis of Novel Quinazoline Congeners via Copper Catalyzed C–N/C–S Coupling and Their Biological Evaluation

Harshad P. Lakum, Dhruvin R. Shah, Kishor H. Chikhalia

Journal of Heterocyclic Chemistry > 53 > 1 > 209 - 219

A library of novel quinazoline scaffolds endowed with semicarbazide/oxadiazole thiol motif synthesized via an efficient and sustainable copper catalyzed C–N/C–S coupling is reported, making the presented methodology extremely valuable from economic and environmental point of view. Among the all synthesized compounds screened for in vitro antibacterial, antifungal, and anti‐TB activity, , , , , , ,...

article

Synthesis of Novel Fused Thiazolo[3,2‐a]pyrimidin‐3‐ols and Evaluation for their Antibacterial Activity

Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Bavantula

Journal of Heterocyclic Chemistry > 53 > 1 > 51 - 55

A series of novel fused thiazolo[3,2‐a]pyrimidin‐3‐ol derivatives have been synthesized by reaction of fused pyrimidine‐thiones with 4‐substituted phenacyl bromide/3(2‐bromoacetyl)coumarin in refluxing acetic acid with good yields. All the synthesized compounds were confirmed by spectral studies and screened for their in vitroantibacterial activity against Staphylococcus aureus, Bacillus thuringiensis...

article

Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine

Yogita K. Abhale, Keshav K. Deshmukh, Amit V. Sasane, Abhijit P. Chavan, more

Journal of Heterocyclic Chemistry > 53 > 1 > 229 - 233

A series of 6‐substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine derivatives is described. The antitubercular activity of the synthesized compounds was determined against Mycobacterium smegmatis MC² 155 strain. From the activity result, it was found that the phenyl or 4‐fluorophenyl group at 2 position of thiazole nucleus and bromo substituent at 6 position of imidazo[1,2‐a]pyridine...

article

A New Energetic Material and its Risk Research

Zhiyue Han, Yinghao Zhang, Qian Yao, Zhiming Du, more

Journal of Heterocyclic Chemistry > 53 > 1 > 325 - 331

Bis (1, 5‐diamino‐4‐methyl‐tetrazolium) azotetrazolate () was synthesized with high yield in this work. The yield is 97.46%. The structure was characterized by IR, ¹H NMR, and MS. The single crystal of BMDATZT•2H₂O was first cultivated. The heat of formation, detonation pressure, and detonation velocity were first calculated. The crystalline density of BMDATZT•2H₂O is 1.573 g/cm³. has high detonation...

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SYNTHESIS (6)
MOLECULAR DOCKING (5)
THIAZOLE (5)
ANTIBACTERIAL ACTIVITY (4)
ANTIMICROBIAL ACTIVITY (4)
PYRAZOLE (4)
ANTIFUNGAL ACTIVITY (3)
PYRIDINE (3)
QUINOLINE (3)
ALUM (2)
ANTIOXIDANT (2)
ENAMINONES (2)
HETEROCYCLES (2)
MICHAEL ADDITION (2)
ONE‐POT SYNTHESIS (2)
THIOPHENE (2)
TOTAL SYNTHESIS (2)
, ANTI‐INFLAMMATORY , ANALGESIC (1)
1,2,4‐OXADIAZOLE (1)
1,2,4‐TRIAZINE (1)
1,2,4‐TRIZAOLE (1)
1,2‐BISPYRIMIDOTRIAZOLOTHIADIAZINETHANE (1)
1,2‐DIAMINOPYRIDONE (1)
1,2‐DIAZOLES (1)
1,3,4‐OXADIAZOLE (1)
1,3,4‐THIADIAZOLES (1)
1,4‐PHENYLENE‐BIS‐THIAZOLYL DERIVATIVES (1)
1,5‐BENZOTHIAZEPINE (1)
1,6‐BIS‐(1,5,3‐DITHIAZEPAN‐3‐YL)‐2,5‐DISULPHANYLHEXANE (1)
15‐LIPOXYGENASE INHIBITOR (1)
1H‐PYRAZOLE‐5‐CARBOXYLATES (1)
1‐(2‐OXO‐2‐ARYLETHYL)PYRIDIN‐1‐IUM (1)
2,3,4,9‐TETRAHYDRO‐1H‐CARBAZOL‐1‐ONE (1)
2,4,6‐TRICHLORO‐1,3,5‐TRIAZINE (1)
2,4,6‐TRICHLORO‐1,3,5‐TRIAZINE (S‐TRIAZINE) (1)
2‐AMINOPYRIDINES (1)
2‐AMINO‐4H‐CHROMENE (1)
2‐OXO‐2H‐CHROMENE‐3‐CARBOXYLIC ACID (1)
2‐PYRIDONE (1)
3,7‐DITHIA‐1,5‐DIAZABICYCLO[3.3.1]NONANE (1)
3‐NITROIMIDAZO[1,2‐A]PYRIDINES (1)
3‐SUBSTITUTED PYRROLIDINE‐2,5‐DIONES (1)
3‐UREIDOFORMIMIDO‐INDOL‐2‐ONES (1)
4H‐PYRAN (1)
4‐AMINO‐5‐HYDRAZINO‐4H‐[1,2,4]‐TRIAZOLE‐3‐THIOL (1)
4‐ARYL‐2,4‐DIKETOESTERS (1)
4‐BROMOACETYL PHENACYL BROMIDE (1)
ACE INHIBITORS (1)
ACETYLCHOLINESTERASE INHIBITION (1)
ALDEHYDE (1)
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ALKYLATION (1)
AMBRISENTAN (1)
AMINE (1)
AMINO PHOSPHONATES (1)
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ANGIOGENESIS (1)
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API (1)
AQUEOUS MEDIA AND CYTOTOXIC ACTIVITY (1)
AROMATIC NITRILE OXIDES (1)
ARYL SUBSTITUTED HYDRAZONO‐PYRAZOLYL‐[1,2,4]TRIAZOLO[3,4‐B][1,3,4][THIADIAZOL]‐COUMARIN (1)
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AZETIDINONE (1)
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BENZIMIDAZOLE (1)
BENZIMIDAZOLONE (1)
BENZOBISIMIDAZOLE (1)
BENZOTHIAZOLE (1)
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BENZOXAZOLE (1)
BENZOXAZOLES (1)
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Journal of Heterocyclic Chemistry

Ag Loaded on SiO₂ as an Efficient and Recyclable Heterogeneous Catalyst for the Synthesis of Chloro‐8‐substituted‐9H‐purines

Synthesis and Antitumor Activity Evaluation of Some Novel‐Fused and Spiro Heterocycles Derived from a 2(3H)‐Furanone Derivative

Natural Product‐Mimetic Scaffolds with Privileged Heterocyclic Systems: Design, Synthesis, and Evaluation of Antioxidant Activity of Quinazoquinobenzothiazinones

Synthesis of Cycloalk[b]indole Bearing Spiropiperidine Derivatives

Synthesis and Properties of Photochromic Diarylethenes Bearing Thiazole Moiety

Synthesis and Biological Activities of Novel 6‐Alkylamino‐11,12‐dihydro‐11‐arylbenzo[c]phenanthridine Derivatives

Synthesis and Molecular Docking Studies of Novel 2‐Phenyl‐4‐Substituted Oxazole Derivatives as Potential Anti‐cancer Agents

One‐Pot Synthesis of Some Dynamic 2‐Substituted Benzoxazinones and Their Corresponding Qinazolinones of Anticipated Biological Activity

Csp²–O and C–C Bond Formation via Pd‐Catalyzed Coupling Reaction of 2,4‐Dichloroquinazoline

Synthesis and Characterization of Bisimidazoles, Bistriazoles, Bisthiadiazoles, and Bisthiazoles from Novel Bishydrazonoyl Dichlorides

Synthesis and Biological Activity of Ethyl 4‐Alkyl‐2‐(2‐(substituted phenoxy)acetamido)thiazole‐5‐carboxylate

Design, Synthesis and Evaluation of Antibacterial Effects of a New Class of Piperazinylquinolone Derivatives

Regioselective and Stereoselective Synthesis of Pyridine‐Fused Benzoxepine Derivatives by Intramolecular Reductive Heck Cyclization [1]

Synthesis of 2‐Phenylquinoline and its Derivatives by Multicomponent Reaction of Aniline, Benzylamine, Alcohols, and CCl₄ Catalyzed by FeCl₃·6H₂O

A Systematic Study on the Synthesis of n‐Butyl Substituted 8‐Aminoquinolines

Synthesis of Novel Indolo‐Spirocyclic Compounds

Convenient Synthesis of Novel Quinazoline Congeners via Copper Catalyzed C–N/C–S Coupling and Their Biological Evaluation

Synthesis of Novel Fused Thiazolo[3,2‐a]pyrimidin‐3‐ols and Evaluation for their Antibacterial Activity

Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine

A New Energetic Material and its Risk Research

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