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The therapeutic efficacy of neurological agents is severely limited, because large compounds do not cross the blood-brain barrier (BBB). Focused ultrasound (FUS) sonication in the presence of microbubbles has been shown to temporarily open the BBB, allowing systemically administered agents into the brain. Until now, polydispersed microbubbles (1-10 ??m in diameter) were used, and, therefore, the bubble...
The blood-brain barrier (BBB) is a specialized brain protection system consisting of endothelial cell, tight junctions and glial processes. BBB is the major limiting factor to therapeutic agents to the brain for disease treatment. Focused ultrasound (FUS) in the presence of microbubbles has the capability to deliver large molecules across BBB. In this study, we qualitatively and quantitatively analyzed...
The delivery of gadolinium through the ultrasound- induced blood-brain barrier (BBB) openings of mice was investigated. The left hippocampus of mice (n=13) was sonicated (frequency: 1.525 MHz, pressure amplitude: 0.64 MPa, duty cycle: 20%, duration: 1 minute) in vivo through the intact skin and skull after the injection of pre-formed microbubbles (SonoVuereg; 25-30 mul). The BBB opening in mice was...
Most neurologically potent drugs cannot be delivered to the brain because of its distinct vasculature: the blood-brain barrier (BBB). Focused ultrasound (FUS) has been shown to produce reversible and localized BBB opening when applied in the presence of microbubbles [Hynynen, K, 2001]. In this study, the dependence of microbubble concentration and vessel type distribution in the targeted brain region...
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