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In this work a synergistic approach is used to investigate how directional anisotropic surfaces (i.e., nanogratings) control the alignment of PC12 neurites. Finite Element models were used to assess the distribution of stresses in non-spread growth cones and filopodia. The stress field was assumed to be the main triggering cause fostering the increase and stabilization of filopodia, so the local stress...
In this paper a thin film intrafascicular interface has been modeled during the insertion procedure inside peripheral nerves using a theoretical approach and a FEM analysis. In particular, the aim was to investigate the effects of several characteristics of the intraneural interfaces (e.g., the interface width and Kevlar filament diameter) on the maximal Von Mises stress reached during implantation...
Sieve peripheral neural interfaces are a very promising solution to develop an intimate connection between the peripheral nervous system and artificial devices (in particular hand prostheses for amputees). However, they present several drawbacks limiting their usability. For this reason we are trying to develop a new generation of sieve interfaces based on the selective control of axonal regeneration...
The possibility of controlling axonal outgrowth during neural regeneration could be very interesting from a neurobiological point of view. It could also allow the development of a new generation of sieve peripheral neural interfaces. They could create an intimate bi-directional link between the nervous system and artificial devices overcoming many of the limits of current interfaces and allowing the...
The development of interfaces linking the human nervous system with artificial devices is an important area of research and several groups are now addressing it. Interfaces represent the key enabling technology for the development of devices usable for the restoration of motor and sensory function in subjects affected by neurological disorders, injuries or amputations. For example, current hand prostheses...
The development of interfaces linking the human nervous system with artificial devices is an important area of research and several groups are now addressing it. Interfaces represent the key enabling technology for the development of devices usable for the restoration of motor and sensory function in subjects affected by neurological disorders, injuries or amputations. For example, current hand prostheses...
The development of interfaces linking the human nervous system with artificial devices is an important area of research and several groups are now addressing it. Interfaces represent the key enabling technology for the development of devices usable for the restoration of motor and sensory function in subjects affected by neurological disorders, injuries or amputations. For example, current hand prostheses...
Several neural interfaces have been developed to control neuroprostheses and hybrid bionic systems. Among them, intraneural electrodes are very promising because they represent an interesting trade-off between the needs for high selectivity and for reduced invasiveness. However, in most of the cases, no particular attention has been devoted so far to the design of these systems starting from the mechanical...
Quantity, duration, content, and intensity of training sessions are very important in order to increase the efficacy of neurorehabilitation. Unfortunately, when traditional therapy is provided in a hospital or rehabilitation center, the patient is usually seen for few hours a week. Robot-mediated therapies could improve this situation. The aim of this work was to verify the possibility of improving...
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