Search results for: Beata R. Frydel

Items from 1 to 9 out of 9 results

article

Subarachnoid Transplant of a Human Neuronal Cell Line Attenuates Chronic Allodynia and Hyperalgesia After Excitotoxic Spinal Cord Injury in the Rat

Mary J. Eaton, Stacey Quintero Wolfe, Miguel Martinez, Massiel Hernandez, more

Journal of Pain > 2007 > 8 > 1 > 33-50

The relief of neuropathic pain after spinal cord injury (SCI) remains daunting, because pharmacologic intervention works incompletely and is accompanied by multiple side effects. Transplantation of human cells that make specific biologic agents that can potentially modulate the sensory responses that are painful would be very useful to treat problems such as pain. To address this need for clinically...

article

Improved neural progenitor cell survival when cografted with chromaffin cells in the rat striatum

Michael A. Schumm, Daniel A. Castellanos, Beata R. Frydel, Jacqueline Sagen

Experimental Neurology > 2004 > 185 > 1 > 133-142

Transplantation of stem and neural progenitor cells hold great promise in the repair of neuronal tissue lost due to injury or disease. However, survival following transplantation to the adult CNS has been poor, likely due to a lack of neurotrophic factors, such as basic fibroblast growth factor (FGF-2), that are used to maintain and expand these cells in culture. Chromaffin cells produce several neurotrophic...

article

Direct cell-cell contact required for neurotrophic effect of chromaffin cells on neural progenitor cells

Michael A. Schumm, Daniel A. Castellanos, Beata R. Frydel, Jacqueline Sagen

Developmental Brain Research > 2003 > 146 > 1-2 > 1-13

Previous studies showed that neural progenitor cultures could be maintained without exogenously added FGF-2 when co-cultured with chromaffin cells. In addition, progenitor cells displayed dramatically increased neuronal differentiation in the presence of chromaffin cells. These findings suggested an approach to improved neural progenitor transplant outcomes using co-transplantation or administration...

article

Analgesic effects of adrenal chromaffin allografts: Contingent on special procedures or due to experimenter bias?

Mark D. Lindner, Beata R. Frydel, Jonathan M. Francis, Chris K. Cain

Journal of Pain > 2003 > 4 > 2 > 64-73

Abstract: Many articles have reported that adrenal chromaffin cell transplants produce analgesic effects. Surprisingly, studies conducted in our laboratory failed to detect analgesic effects of adrenal chromaffin cell transplants. Although we have attempted to replicate the procedures reported to produce analgesic effects with adrenal chromaffin transplants, many of the different cell preparation...

article

No detectable analgesic effects in the formalin test even with one million bovine adrenal chromaffin cells

Amit G. Gulwadi, Michael R. Hoane, Joel A. Saydoff, Beata R. Frydel, more

Pain > 2002 > 99 > 1-2 > 263-271

The present experiments were conducted to identify analgesic agents for transfection into immortalized adrenal chromaffin cell lines to maximize their analgesic potential. Analgesic agents known to be produced by adrenal chromaffin cells were infused intrathecally at a low dose (0.2μg) which might conceivably be attained by adrenal chromaffin cell transplants. Numerous agents, administered individually...

article

Enhanced viability and neuronal differentiation of neural progenitors by chromaffin cell co-culture

Michael A. Schumm, Daniel A. Castellanos, Beata R. Frydel, Jacqueline Sagen

Developmental Brain Research > 2002 > 137 > 2 > 115-125

The transplantation of neural stem cells and progenitors has potential in restoring lost cellular populations following central nervous system (CNS) injury or disease, but survival and neuronal differentiation in the adult CNS may be insufficient in the absence of exogenous trophic support. Adrenal medullary chromaffin cells produce a trophic cocktail including basic fibroblast growth factor (FGF-2)...

article

Adrenal medullary transplants reduce formalin-evoked c-fos expression in the rat spinal cord

Julie B. Siegan, Uri Herzberg, Beata R. Frydel, Jacqueline Sagen

Brain Research > 2002 > 944 > 1-2 > 174-183

Previous studies have indicated that adrenal medullary chromaffin cells transplanted into the spinal subarachnoid space can alleviate pain behaviors in several animal models. The goal of this study was to assess whether decreased activation of spinal dorsal horn neurons responsive to nociceptive stimuli may contribute to these antinociceptive effects. In order to address this, expression of neural...

article

Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats

Mark D. Lindner, Chris K. Cain, Melissa A. Plone, Beata R. Frydel, more

Behavioural Brain Research > 1999 > 102 > 1-2 > 1 - 16

The present study was conducted to determine if the full array of parkinsonian symptoms could be detected in rats with nigrostriatal cell loss and striatal dopamine depletions similar to levels reported in the clinical setting, and to determine if older rats exhibit more robust parkinsonian deficits than younger rats. Young (2 months old) and middle-aged (12 months old) rats received bilateral striatal...

article

Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts

Dwaine F. Ernerich, Melissa Plone, Johnathan Francis, Beata R. Frydel, more

Brain Research > 1996 > 736 > 1-2 > 99-110

The present study examined the effects of encapsulated cells which were genetically modified to secrete human glial-derived neurotrophic factor (hGDNF) on the motor deficits in aged rodents. Prior to implantation, animals were tested on a battery of motor tasks. Spontaneous locomotion and motor coordination was evaluated in young (5 month) and aged (20 month) rats. Aged animals tested for spontaneous...

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Keywords

ADRENAL MEDULLA (2)
FIBROBLAST GROWTH FACTOR (2)
NEURAL TRANSPLANTATION (2)
[NEUROSCIENCE SOCIETY TOPICS] DEVELOPMENT AND REGENERATION (2)
6-OHDA (1)
AGE (1)
AGING (1)
ANALGESIC AGENTS (1)
ANTINOCICEPTION (1)
BEHAVIOR (1)
BOVINE ADRENAL CHROMAFFIN CELLS (1)
CHROMAFFIN CELL (1)
CHROMAFFIN CELLS (1)
DOPAMINE (1)
DORSAL HORN (1)
FOS (1)
GDNF (1)
HNT2 CELLS (1)
INHIBITORY NEUROTRANSMITTER (1)
NEURAL PRECURSOR (1)
NEURAL PRECURSORS (1)
NEURAL PROGENITOR CELLS (1)
NEURAL STEM CELL (1)
NEURAL STEM CELLS (1)
NEURAL TRANSPLANT (1)
NEUROPATHIC PAIN (1)
NEUROTROPHIN (1)
NEUROTROPHINS (1)
NICOTINE STIMULATION (1)
NIGROSTRIATAL CELL COUNTS (1)
PARKINSONIAN SYMPTOMS (1)
PARTIAL LESIONS (1)
POLYMER (1)
QUISQUALIC ACID (1)
RAT STRIATUM (1)
STRIATUM (1)
TRANSPLANT (1)
[NEUROSCIENCE SOCIETY TOPICS] CELL LINEAGE AND DETERMINATION (1)
[NEUROSCIENCE SOCIETY TOPICS] DEVELOPMENT OF NEURONS AND GLIA (1)
[NEUROSCIENCE SOCIETY TOPICS] PAIN MODULATION: ANATOMY AND PHYSIOLOGY (1)
[NEUROSCIENCE SOCIETY TOPICS] SENSORY SYSTEMS (1)
Γ-AMINO BUTYRIC ACID (1)
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